Increased innervation of forebrain targets by midbrain dopaminergic neurons in the absence of FGF-2

Highlights • Lack of FGF-2-LMW is most feasible for misdevelopment of the nigrostriatal system. • FGF-2-deficient mice showed increased volume of the dopaminergic forebrain target. • Blocking the canonical FGFR mimics enlarged forebrain innervation in explants. • FGFR-mediated ERK activation is resp...

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Bibliographic Details
Published in:Neuroscience 2016-02, Vol.314, p.134-144
Main Authors: Rumpel, R, Baron, O, Ratzka, A, Schröder, M.-L, Hohmann, M, Effenberg, A, Claus, P, Grothe, C
Format: Article
Language:English
Subjects:
Animals
Corpus Striatum - cytology
Corpus Striatum - embryology
Corpus Striatum - metabolism
dopaminergic neuron
Dopaminergic Neurons - cytology
Dopaminergic Neurons - metabolism
FGF
Fibroblast Growth Factor 2 - genetics
Fibroblast Growth Factor 2 - metabolism
Fibroblast Growth Factor 2 - physiology
MAP Kinase Signaling System
Mice
Mice, Inbred C57BL
Mice, Knockout
neural development
Neural Pathways - cytology
Neural Pathways - embryology
Neural Pathways - metabolism
Neurology
neurotrophic factor
Prosencephalon
Protein Isoforms - physiology
Proto-Oncogene Proteins c-akt - metabolism
Receptor, Fibroblast Growth Factor, Type 1 - metabolism
Substantia Nigra - cytology
Substantia Nigra - embryology
Substantia Nigra - metabolism
Tyrosine 3-Monooxygenase - metabolism
ventral midbrain
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Summary:Highlights • Lack of FGF-2-LMW is most feasible for misdevelopment of the nigrostriatal system. • FGF-2-deficient mice showed increased volume of the dopaminergic forebrain target. • Blocking the canonical FGFR mimics enlarged forebrain innervation in explants. • FGFR-mediated ERK activation is responsible for adequate forebrain innervation.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.11.057