Annexin A2 in primary afferents contributes to neuropathic pain associated with tissue type plasminogen activator

Highlights • Peripheral nerve injury induced ANX2 and tPA in the primary afferent. • Administration of the inhibitor for ANX2–tPA complex suppressed neuropathic pain. • The role ANX2–tPA complex may be involved in the plastic changes in dorsal horn.

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Bibliographic Details
Published in:Neuroscience 2016-02, Vol.314, p.189-199
Main Authors: Yamanaka, H, Kobayashi, K, Okubo, M, Noguchi, K
Format: Article
Language:English
Subjects:
Animals
annexin A2
Annexin A2 - metabolism
dorsal horn
dorsal root ganglia
Ganglia, Spinal - metabolism
Hydrolases - administration & dosage
Hyperalgesia - chemically induced
Male
Neuralgia - etiology
Neuralgia - metabolism
Neuroglia - metabolism
Neurology
neuropathic pain
Pain Threshold - drug effects
Peripheral Nerve Injuries - complications
Peroneal Nerve - injuries
plasticity
Rats
Rats, Sprague-Dawley
RNA, Messenger - metabolism
Tibial Nerve - injuries
Tissue Plasminogen Activator - administration & dosage
Tissue Plasminogen Activator - metabolism
tissue type plasminogen activator (tPA)
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Description
Summary:Highlights • Peripheral nerve injury induced ANX2 and tPA in the primary afferent. • Administration of the inhibitor for ANX2–tPA complex suppressed neuropathic pain. • The role ANX2–tPA complex may be involved in the plastic changes in dorsal horn.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.11.058