Is the interaction between fatty acids and tryptophan responsible for the efficacy of a ketogenic diet in epilepsy? The new hypothesis of action

Highlights • Fatty acids increased the brain levels of tryptophan and kynurenic acid (KYNA). • The antiseizure action of octanoic fatty acid may be related to changes in tryptophan metabolism. • The octanoic fatty acid is crucial for antiseizure activity of medium-chain triglyceride ketogenic diet....

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Bibliographic Details
Published in:Neuroscience 2016-01, Vol.313, p.130-148
Main Authors: Maciejak, P, Szyndler, J, Turzyńska, D, Sobolewska, A, Kołosowska, K, Krząścik, P, Płaźnik, A
Format: Article
Language:English
Subjects:
Animals
Brain - drug effects
Brain - metabolism
Diet, Ketogenic
Epilepsy - diet therapy
Epilepsy - metabolism
Fatty Acids - administration & dosage
Fatty Acids - metabolism
Hypnotics and Sedatives - administration & dosage
Implantable Neurostimulators
ketogenic diet
Ketone Bodies - metabolism
kynurenic acid
Kynurenic Acid - metabolism
Male
Models, Neurological
NAD+/NADH ratio
Neurology
octanoic and decanoic fatty acids
Rats, Wistar
seizure activity
Treatment Outcome
tryptophan
Tryptophan - metabolism
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Summary:Highlights • Fatty acids increased the brain levels of tryptophan and kynurenic acid (KYNA). • The antiseizure action of octanoic fatty acid may be related to changes in tryptophan metabolism. • The octanoic fatty acid is crucial for antiseizure activity of medium-chain triglyceride ketogenic diet.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.11.029