LncRNA- UCA1 exerts oncogenic functions in non-small cell lung cancer by targeting miR-193a-3p

Highlights • Higher expression of UCA1 is significantly associated with poorer survival time. • UCA1 overexpression enhanced the proliferation and colony formation of NSCLC cells. • ERBB4 is upregulated by UCA1 through competitively ‘spongeing’ miR-193a-3p.

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Bibliographic Details
Published in:Cancer letters 2016-02, Vol.371 (1), p.99-106
Main Authors: Nie, Wei, Ge, Hui-juan, Yang, Xiao-qun, Sun, Xiangjie, Huang, Hai, Tao, Xia, Chen, Wan-sheng, Li, Bing
Format: Article
Language:English
Subjects:
Binding sites
Carcinoma, Non-Small-Cell Lung - genetics
Carcinoma, Non-Small-Cell Lung - metabolism
Carcinoma, Non-Small-Cell Lung - mortality
Carcinoma, Non-Small-Cell Lung - pathology
Carcinoma, Non-Small-Cell Lung - therapy
Cell growth
Cell Line, Tumor
Cell Proliferation
Chemotherapy
Chi-Square Distribution
Confidence intervals
ERBB4
Female
Gene expression
Gene Expression Regulation, Neoplastic
Hematology, Oncology and Palliative Medicine
Humans
Kaplan-Meier Estimate
Liver cancer
lncRNA
Lung cancer
Lung Neoplasms - genetics
Lung Neoplasms - metabolism
Lung Neoplasms - mortality
Lung Neoplasms - pathology
Lung Neoplasms - therapy
Male
Manufacturers
Medical prognosis
Metastasis
MicroRNAs - genetics
MicroRNAs - metabolism
Middle Aged
miR-193a-3p
Mortality
Multivariate Analysis
Non-small cell lung cancer
Oncogenes
Proportional Hazards Models
Proteins
Receptor, ErbB-4 - genetics
Receptor, ErbB-4 - metabolism
Retrospective Studies
Risk Factors
RNA Interference
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
Time Factors
Transfection
Treatment Outcome
UCA1
Up-Regulation
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Description
Summary:Highlights • Higher expression of UCA1 is significantly associated with poorer survival time. • UCA1 overexpression enhanced the proliferation and colony formation of NSCLC cells. • ERBB4 is upregulated by UCA1 through competitively ‘spongeing’ miR-193a-3p.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2015.11.024