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LncRNA- UCA1 exerts oncogenic functions in non-small cell lung cancer by targeting miR-193a-3p
Highlights • Higher expression of UCA1 is significantly associated with poorer survival time. • UCA1 overexpression enhanced the proliferation and colony formation of NSCLC cells. • ERBB4 is upregulated by UCA1 through competitively ‘spongeing’ miR-193a-3p.
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| Published in: | Cancer letters 2016-02, Vol.371 (1), p.99-106 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c478t-e4e1bf64ee9d7836dce117adcfe2b24e53d7d24604e60d700e766689fbf8b98c3 |
| container_end_page | 106 |
| container_issue | 1 |
| container_start_page | 99 |
| container_title | Cancer letters |
| container_volume | 371 |
| creator | Nie, Wei Ge, Hui-juan Yang, Xiao-qun Sun, Xiangjie Huang, Hai Tao, Xia Chen, Wan-sheng Li, Bing |
| description | Highlights • Higher expression of UCA1 is significantly associated with poorer survival time. • UCA1 overexpression enhanced the proliferation and colony formation of NSCLC cells. • ERBB4 is upregulated by UCA1 through competitively ‘spongeing’ miR-193a-3p. |
| doi_str_mv | 10.1016/j.canlet.2015.11.024 |
| format | article |
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genetics</subject><subject>Carcinoma, Non-Small-Cell Lung - metabolism</subject><subject>Carcinoma, Non-Small-Cell Lung - mortality</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Carcinoma, Non-Small-Cell Lung - therapy</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation</subject><subject>Chemotherapy</subject><subject>Chi-Square Distribution</subject><subject>Confidence intervals</subject><subject>ERBB4</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Liver cancer</subject><subject>lncRNA</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - genetics</subject><subject>Lung Neoplasms - metabolism</subject><subject>Lung Neoplasms - mortality</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - therapy</subject><subject>Male</subject><subject>Manufacturers</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Middle Aged</subject><subject>miR-193a-3p</subject><subject>Mortality</subject><subject>Multivariate Analysis</subject><subject>Non-small cell lung cancer</subject><subject>Oncogenes</subject><subject>Proportional Hazards Models</subject><subject>Proteins</subject><subject>Receptor, ErbB-4 - genetics</subject><subject>Receptor, ErbB-4 - metabolism</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>RNA Interference</subject><subject>RNA, Long Noncoding - genetics</subject><subject>RNA, Long Noncoding - metabolism</subject><subject>Time Factors</subject><subject>Transfection</subject><subject>Treatment Outcome</subject><subject>UCA1</subject><subject>Up-Regulation</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqFkl2L1DAUhoMo7rj6D0QC3njTevLd3gjD4BcMCqt7a2jT0yFjm45JK86_N2VWhb3xJoHwnJM3Tw4hzxmUDJh-fSxdEwacSw5MlYyVwOUDsmGV4YWpK3hINiBAFqIS6oo8SekIAEoa9Zhcca2V4oZvyLd9cDeftgW93W0ZxV8Y50Sn4KYDBu9ovwQ3-ykk6gMNUyjS2AwDdZiXYQkHmjM4jLQ907mJB5x9Phv9TcFq0RTi9JQ86psh4bO7_Zrcvnv7dfeh2H9-_3G33RdOmmouUCJrey0R685UQncOGTNN53rkLZeoRGc6LjVI1NAZADRa66ru275q68qJa_Lq0vcUpx8LptmOPq0pm4DTkiwzmgsNGnhGX95Dj9MSQ06XKSWkVFlopuSFcnFKKWJvT9GPTTxbBnb1b4_24t-u_i1jNvvPZS_umi_tiN3foj_CM_DmAmC28dNjtMl5zA47H9HNtpv8_26438ANPn9VM3zHM6Z_b7GJW7Bf1hlYR4ApgCxOit-5YKrm</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Nie, Wei</creator><creator>Ge, Hui-juan</creator><creator>Yang, Xiao-qun</creator><creator>Sun, Xiangjie</creator><creator>Huang, Hai</creator><creator>Tao, Xia</creator><creator>Chen, Wan-sheng</creator><creator>Li, Bing</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20160201</creationdate><title>LncRNA- UCA1 exerts oncogenic functions in non-small cell lung cancer by targeting miR-193a-3p</title><author>Nie, Wei ; Ge, Hui-juan ; Yang, Xiao-qun ; Sun, Xiangjie ; Huang, Hai ; Tao, Xia ; Chen, Wan-sheng ; Li, Bing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-e4e1bf64ee9d7836dce117adcfe2b24e53d7d24604e60d700e766689fbf8b98c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Binding sites</topic><topic>Carcinoma, Non-Small-Cell Lung - genetics</topic><topic>Carcinoma, Non-Small-Cell Lung - metabolism</topic><topic>Carcinoma, Non-Small-Cell Lung - mortality</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Carcinoma, Non-Small-Cell Lung - therapy</topic><topic>Cell growth</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation</topic><topic>Chemotherapy</topic><topic>Chi-Square Distribution</topic><topic>Confidence intervals</topic><topic>ERBB4</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Liver cancer</topic><topic>lncRNA</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - genetics</topic><topic>Lung Neoplasms - metabolism</topic><topic>Lung Neoplasms - mortality</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - therapy</topic><topic>Male</topic><topic>Manufacturers</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>MicroRNAs - 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| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 2016-02, Vol.371 (1), p.99-106 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | Elsevier |
| subjects | Binding sites Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - therapy Cell growth Cell Line, Tumor Cell Proliferation Chemotherapy Chi-Square Distribution Confidence intervals ERBB4 Female Gene expression Gene Expression Regulation, Neoplastic Hematology, Oncology and Palliative Medicine Humans Kaplan-Meier Estimate Liver cancer lncRNA Lung cancer Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - mortality Lung Neoplasms - pathology Lung Neoplasms - therapy Male Manufacturers Medical prognosis Metastasis MicroRNAs - genetics MicroRNAs - metabolism Middle Aged miR-193a-3p Mortality Multivariate Analysis Non-small cell lung cancer Oncogenes Proportional Hazards Models Proteins Receptor, ErbB-4 - genetics Receptor, ErbB-4 - metabolism Retrospective Studies Risk Factors RNA Interference RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Time Factors Transfection Treatment Outcome UCA1 Up-Regulation |
| title | LncRNA- UCA1 exerts oncogenic functions in non-small cell lung cancer by targeting miR-193a-3p |
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