Role of brain aldosterone and mineralocorticoid receptors in aldosterone-salt hypertension in rats

Graphical abstract SFO lesion, central infusion of an aldosterone synthase inhibitor or MR blocker and knockdown of MR or AT1 R expression in the PVN similarly prevent ∼70% of aldosterone-salt hypertension. Central mechanisms appear to play a major role in the hypertension induced by aldosterone-sal...

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Bibliographic Details
Published in:Neuroscience 2016-02, Vol.314, p.90-105
Main Authors: Wang, H.-W, Huang, B.S, Chen, A, Ahmad, M, White, R.A, Leenen, F.H.H
Format: Article
Language:English
Subjects:
aldosterone
Aldosterone - administration & dosage
Aldosterone - metabolism
aldosterone synthase
angiotensin II type 1 receptor
Animals
Arterial Pressure - drug effects
brain
Corticosterone - metabolism
Cytochrome P-450 CYP11B2 - antagonists & inhibitors
Drinking Behavior - drug effects
Fadrozole - administration & dosage
gene expression knockdown
Hypertension - chemically induced
Hypertension - metabolism
Hypertension - physiopathology
Male
mineralocorticoid receptor
Mineralocorticoid Receptor Antagonists - administration & dosage
Neurology
Neurons - drug effects
Neurons - metabolism
Paraventricular Hypothalamic Nucleus - drug effects
Paraventricular Hypothalamic Nucleus - metabolism
Rats
Rats, Wistar
Receptors, Mineralocorticoid - metabolism
RNA, Messenger - metabolism
Sodium Chloride - administration & dosage
Spironolactone - administration & dosage
Spironolactone - analogs & derivatives
Subfornical Organ - drug effects
Subfornical Organ - metabolism
Supraoptic Nucleus - drug effects
Supraoptic Nucleus - metabolism
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Description
Summary:Graphical abstract SFO lesion, central infusion of an aldosterone synthase inhibitor or MR blocker and knockdown of MR or AT1 R expression in the PVN similarly prevent ∼70% of aldosterone-salt hypertension. Central mechanisms appear to play a major role in the hypertension induced by aldosterone-salt.* p < 0.05, vs. other groups.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.11.055