The Wide World of Ribosomally Encoded Bacterial Peptides: e1004221

Bacterial peptides produced by both gram-positive and gram-negative bacteria include antimicrobial peptides such as Nisin and Microcin B17, known host virulence factors such as the Streptolysin S-like cytolysins, and the peptide cytolysin from E. faecalis. Streptolysin S has been identified as a maj...

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Bibliographic Details
Published in:PLoS pathogens 2014-07, Vol.10 (7)
Main Authors: Flaherty, Rebecca A, Freed, Stefan D, Lee, Shaun W
Format: Article
Language:English
Subjects:
Antimicrobial agents
Bacteria
Bacteriology
E coli
Enzymes
Genes
Genetic engineering
Genomes
Metabolites
Natural products
Peptides
Streptococcus infections
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Summary:Bacterial peptides produced by both gram-positive and gram-negative bacteria include antimicrobial peptides such as Nisin and Microcin B17, known host virulence factors such as the Streptolysin S-like cytolysins, and the peptide cytolysin from E. faecalis. Streptolysin S has been identified as a major contributing factor in successful translocation of Streptococcus pyogenes across the epithelial barrier through a mechanism involving the disruption of intracellular junctions via cleavage of occludin and E-cadherin [13].\n Bacteriocin-like peptides are highly attractive candidates for genome mining, as these natural products are genetically encoded with nearby genes encoding their corresponding modifying enzymes.
ISSN:1553-7366
1553-7374
DOI:10.1371/journal.ppat.1004221