Acquired and Transmitted Multidrug Resistant Tuberculosis: The Role of Social Determinants: e0146642

Although risk factors for multi-drug resistant tuberculosis are known, few studies have differentiated between acquired and transmitted resistance. It is important to identify factors associated with these different mechanisms to optimize control measures. We conducted a prospective cohort study of...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2016-01, Vol.11 (1)
Main Authors: Odone, Anna, Calderon, Roger, Becerra, Mercedes C, Zhang, Zibiao, Contreras, Carmen C, Yataco, Rosa, Galea, Jerome, Lecca, Leonid, Bonds, Matthew H, Mitnick, Carole D
Format: Article
Language:English
Subjects:
Mycobacterium
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Although risk factors for multi-drug resistant tuberculosis are known, few studies have differentiated between acquired and transmitted resistance. It is important to identify factors associated with these different mechanisms to optimize control measures. We conducted a prospective cohort study of index TB patients and their household contacts in Lima, Peru to identify risk factors associated with acquired and transmitted resistance, respectively. Patients with higher socioeconomic status (SES) had a 3-fold increased risk of transmitted resistance compared to those with lower SES when acquired resistance served as the baseline. Quality of housing mediated most of the impact of SES.
ISSN:1932-6203
DOI:10.1371/journal.pone.0146642