Acquired and Transmitted Multidrug Resistant Tuberculosis: The Role of Social Determinants: e0146642

Although risk factors for multi-drug resistant tuberculosis are known, few studies have differentiated between acquired and transmitted resistance. It is important to identify factors associated with these different mechanisms to optimize control measures. We conducted a prospective cohort study of...

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Published in:PloS one 2016-01, Vol.11 (1)
Main Authors: Odone, Anna, Calderon, Roger, Becerra, Mercedes C, Zhang, Zibiao, Contreras, Carmen C, Yataco, Rosa, Galea, Jerome, Lecca, Leonid, Bonds, Matthew H, Mitnick, Carole D
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Mycobacterium
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container_title PloS one
container_volume 11
creator Odone, Anna
Calderon, Roger
Becerra, Mercedes C
Zhang, Zibiao
Contreras, Carmen C
Yataco, Rosa
Galea, Jerome
Lecca, Leonid
Bonds, Matthew H
Mitnick, Carole D
description Although risk factors for multi-drug resistant tuberculosis are known, few studies have differentiated between acquired and transmitted resistance. It is important to identify factors associated with these different mechanisms to optimize control measures. We conducted a prospective cohort study of index TB patients and their household contacts in Lima, Peru to identify risk factors associated with acquired and transmitted resistance, respectively. Patients with higher socioeconomic status (SES) had a 3-fold increased risk of transmitted resistance compared to those with lower SES when acquired resistance served as the baseline. Quality of housing mediated most of the impact of SES.
doi_str_mv 10.1371/journal.pone.0146642
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title Acquired and Transmitted Multidrug Resistant Tuberculosis: The Role of Social Determinants: e0146642
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