Preoperative Neutrophil-to-Lymphocyte Ratio is a Better Prognostic Serum Biomarker than Platelet-to-Lymphocyte Ratio in Patients Undergoing Resection for Nonmetastatic Colorectal Cancer

Introduction Current risk stratification tools for patients with colorectal cancer (CRC) rely on final surgical pathology but may be improved with the addition of novel serum biomarkers. The objective of this study was to evaluate the utility of preoperative NLR and PLR in predicting long-term oncol...

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Bibliographic Details
Published in:Annals of surgical oncology 2015-12, Vol.22 (Suppl 3), p.603-613
Main Authors: Choi, Woo Jin, Cleghorn, Michelle C., Jiang, Haiyan, Jackson, Timothy D., Okrainec, Allan, Quereshy, Fayez A.
Format: Article
Language:English
Subjects:
Adenocarcinoma, Mucinous - pathology
Adenocarcinoma, Mucinous - surgery
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - analysis
Blood Platelets - pathology
Colorectal Cancer
Colorectal Neoplasms - pathology
Colorectal Neoplasms - surgery
Female
Follow-Up Studies
Humans
Lymphocytes - pathology
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - surgery
Neoplasm Staging
Neutrophils - pathology
Oncology
Preoperative Care
Prognosis
Surgery
Surgical Oncology
Survival Rate
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Summary:Introduction Current risk stratification tools for patients with colorectal cancer (CRC) rely on final surgical pathology but may be improved with the addition of novel serum biomarkers. The objective of this study was to evaluate the utility of preoperative NLR and PLR in predicting long-term oncologic outcomes in patients with operable CRC. Methods All patients who underwent curative resection for adenocarcinoma at a large tertiary academic hospital were identified. High NLR/PLR was evaluated preoperatively and defined by maximizing log-rank statistics. Recurrence-free survival (RFS) and overall survival (OS) were calculated using the Kaplan–Meier method and compared by the log-rank test. Univariate and multivariable Cox proportional hazard regression was used to identify associations with outcome measures. Results A total of 549 patients were included in the study. High NLR (≥2.6) was associated with worse RFS (hazard ratio [HR] 2.03, 95 % confidence interval [CI] 1.48 – 2.79, p  
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-015-4571-7