Increased Platelet to Lymphocyte Ratio is Related to Slow Coronary Flow

Previous studies showed that both inflammation and platelets have a role in development of slow coronary flow (SCF). Platelet to lymphocyte ratio (PLR) as an emerging inflammatory indicator was significantly associated with adverse cardiovascular events. Therefore, we aimed to assess the relationshi...

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Bibliographic Details
Published in:Angiology 2016-01, Vol.67 (1), p.21-26
Main Authors: Akboga, Mehmet Kadri, Canpolat, Ugur, Balci, Kevser Gulcihan, Akyel, Ahmet, Sen, Fatih, Yayla, Cagri, Cay, Serkan, Aras, Dursun, Aydogdu, Sinan
Format: Article
Language:English
Subjects:
Blood Cell Count
Blood Platelets - metabolism
Coronary Angiography
Coronary Circulation - physiology
Female
Follow-Up Studies
Humans
Lymphocytes - metabolism
Male
Middle Aged
No-Reflow Phenomenon - blood
No-Reflow Phenomenon - diagnostic imaging
No-Reflow Phenomenon - physiopathology
Prognosis
Retrospective Studies
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Summary:Previous studies showed that both inflammation and platelets have a role in development of slow coronary flow (SCF). Platelet to lymphocyte ratio (PLR) as an emerging inflammatory indicator was significantly associated with adverse cardiovascular events. Therefore, we aimed to assess the relationship between PLR and SCF. Patients who had angiographically normal coronary arteries were enrolled in this retrospective study (n = 221 as SCF group and n = 293 as control group). Patients who had thrombolysis in myocardial infarction frame counts (TFC) above the normal cutoffs were considered to have SCF. Both PLR and C-reactive protein (CRP) were significantly higher in the SCF group. In correlation analysis, PLR has a significantly positive correlation with the left anterior descending artery TFC (P = .001), circumflex artery TFC (P < .001), right coronary artery TFC (P < .001), and serum CRP level (P < .001). In multiple logistic regression analysis, PLR was independently associated with presence of SCF (odds ratio: 1.014, P < .001). In conclusion, higher PLR levels were significantly and independently related to the presence of SCF. Besides, PLR was positively correlated with serum CRP level as a conventional marker for systemic inflammation.
ISSN:0003-3197
1940-1574
DOI:10.1177/0003319715574625