The FKBP5 polymorphism rs1360780 influences the effect of an algorithm-based antidepressant treatment and is associated with remission in patients with major depression

Objective: The FKBP5-gene influences the HPA-system by modulating the sensitivity of the glucocorticoid receptor (GR). The polymorphism rs1360780 has been associated with response in studies with heterogeneous antidepressant treatment. In contrast, several antidepressant studies with standardized an...

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Bibliographic Details
Published in:Journal of psychopharmacology (Oxford) 2016-01, Vol.30 (1), p.40-47
Main Authors: Stamm, Thomas J, Rampp, Carina, Wiethoff, Katja, Stingl, Julia, Mössner, Rainald, O′Malley, Grace, Ricken, Roland, Seemüller, Florian, Keck, Martin, Fisher, Robert, Gaebel, Wolfgang, Maier, Wolfgang, Möller, Hans-Jürgen, Bauer, Michael, Adli, Mazda
Format: Article
Language:English
Subjects:
Adult
Algorithms
Alleles
Antidepressants
Antidepressive Agents - therapeutic use
Depressive Disorder, Major - drug therapy
Depressive Disorder, Major - genetics
Depressive Disorder, Major - physiopathology
Female
Genotype
Germany
Humans
Male
Medical treatment
Mental depression
Middle Aged
Polymorphism
Polymorphism, Single Nucleotide
Psychiatric Status Rating Scales
Psychopharmacology
Remission Induction
Tacrolimus Binding Proteins - genetics
Treatment Outcome
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Summary:Objective: The FKBP5-gene influences the HPA-system by modulating the sensitivity of the glucocorticoid receptor (GR). The polymorphism rs1360780 has been associated with response in studies with heterogeneous antidepressant treatment. In contrast, several antidepressant studies with standardized antidepressant treatment could not detect this effect. We therefore compared patients with standardized vs naturalistic antidepressant treatment to (a) investigate a possible interaction between FKBP5-genotype and treatment mode and (b) replicate the effect of the FKBP5-genotype on antidepressant treatment outcome. Methods: A total of 298 major depressive disorder (MDD) inpatients from the multicentred German project and the Zurich Algorithm Project were genotyped for their FKBP5 status. Patients were treated as usual (n=127) or according to a standardized algorithm (n=171). Main outcome criteria was remission (Hamilton Depression Rating Scale-21
ISSN:0269-8811
1461-7285
DOI:10.1177/0269881115620459