Helicobacter Pylori Infection: Diagnostic Strategies in Primary Diagnosis and After Therapy

Accurate diagnosis of Helicobacter pylori infection pre- and post-treatment is mandatory in the current era of decreasing prevalence and increasing antibiotic resistance. The diagnostic performance of most tests is poorer in clinical situations with low bacterial density which is seen in conditions...

Full description

Saved in:
Bibliographic Details
Published in:Digestive diseases and sciences 2016-01, Vol.61 (1), p.19-24
Main Authors: Atkinson, Nathan S. S., Braden, Barbara
Format: Article
Language:English
Subjects:
Antibodies, Bacterial - blood
Antigens, Bacterial - analysis
Bacterial Proteins - analysis
Bacteriological Techniques
Biochemistry
Biomarkers - blood
Biopsy
Breath Tests
Drug resistance in microorganisms
Endoscopy, Gastrointestinal
Feces - microbiology
Gastroenterology
Health aspects
Helicobacter infections
Helicobacter Infections - diagnosis
Helicobacter Infections - drug therapy
Helicobacter Infections - microbiology
Helicobacter pylori
Helicobacter pylori - drug effects
Helicobacter pylori - enzymology
Helicobacter pylori - immunology
Helicobacter pylori - isolation & purification
Hepatology
Humans
Immunoglobulin G - blood
Infection
Medicine
Medicine & Public Health
Oncology
Predictive Value of Tests
Review
Serologic Tests
Transplant Surgery
Treatment Outcome
Urease - analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Accurate diagnosis of Helicobacter pylori infection pre- and post-treatment is mandatory in the current era of decreasing prevalence and increasing antibiotic resistance. The diagnostic performance of most tests is poorer in clinical situations with low bacterial density which is seen in conditions such as atrophic gastritis or intake of antisecretory and antibiotic medications. Noninvasive tests require less cost and resource but provide excellent accuracy; however, endoscopy with testing of gastric biopsy specimens is indicated where alarming symptoms are present or antibiotic susceptibility testing by culture is desired. Newer modalities such as polymerase chain reaction testing provide additional virulence and antibiotic sensitivity profiling. This article outlines new developments and the key parameters of each test, as careful selection of test modality within the clinical context is required for adequate management of infected symptomatic patients.
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-015-3877-4