Helicobacter pylori eradication cannot reduce the risk of gastric cancer in patients with intestinal metaplasia and dysplasia: evidence from a meta-analysis

Background The effect of Helicobacter pylori ( H. pylori ) eradication on gastric cancer (GC) prevention is controversial. Intestinal metaplasia (IM) seems to be a “point of no return” in the precancerous cascade. We performed a meta-analysis of randomized controlled trials (RCTs) to illustrate this...

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Bibliographic Details
Published in:Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2016-01, Vol.19 (1), p.166-175
Main Authors: Chen, Hai-Ning, Wang, Zhu, Li, Xiao, Zhou, Zong-Guang
Format: Article
Language:English
Subjects:
Abdominal Surgery
Cancer Research
Gastric cancer
Gastric Mucosa - microbiology
Gastric Mucosa - pathology
Gastritis, Atrophic - complications
Gastritis, Atrophic - microbiology
Gastritis, Atrophic - pathology
Gastroenterology
Helicobacter Infections - complications
Helicobacter Infections - drug therapy
Helicobacter Infections - pathology
Helicobacter pylori
Humans
Medicine
Medicine & Public Health
Metaplasia - microbiology
Oncology
Original Article
Precancerous Conditions - microbiology
Precancerous Conditions - pathology
Precancerous Conditions - prevention & control
Randomized Controlled Trials as Topic
Stomach Neoplasms - microbiology
Stomach Neoplasms - pathology
Stomach Neoplasms - prevention & control
Surgical Oncology
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Summary:Background The effect of Helicobacter pylori ( H. pylori ) eradication on gastric cancer (GC) prevention is controversial. Intestinal metaplasia (IM) seems to be a “point of no return” in the precancerous cascade. We performed a meta-analysis of randomized controlled trials (RCTs) to illustrate this issue. Materials and Methods The MEDLINE, EMBASE, Cochrane Library were searched for relevant RCTs that were published in any language up to March 2014. By dividing participants into subgroups based on their baseline diagnoses as group
ISSN:1436-3291
1436-3305
DOI:10.1007/s10120-015-0462-7