Response to immunization in children born to renal transplant recipients using immunosuppressive drugs during gestation

Highlights • Infants born to solid organ transplanted women are exposed to immunosuppression. • Eighty percent of infants born to renal transplant mothers had low B cells at birth. • Adequate humoral response to tetanus, Hib and pneumococcal vaccination was observed. • BCG healing was adequate and s...

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Bibliographic Details
Published in:Vaccine 2016-01, Vol.34 (4), p.404-407
Main Authors: Dinelli, Maria Isabel Saraiva, Ono, Erika, Viana, Patrícia Oliveira, Spina, Fernanda Garcia, Weckx, Lily Yin, dos Santos, Amélia Miyashiro Nunes, Moraes-Pinto, Maria Isabel de
Format: Article
Language:English
Subjects:
Adult
Age
Allergy and Immunology
Antibodies, Bacterial - blood
B-Lymphocytes - cytology
Bacterial Capsules
Drugs
Female
Fetal Blood - cytology
Gestation
Haemophilus influenzae
Haemophilus Vaccines - therapeutic use
Hepatitis
Humans
Hypertension
Immune response
Immune system
Immunity, Humoral
Immunization
Immunoglobulins
Immunosuppression
Immunosuppressive Agents - therapeutic use
Infant
Infant, Newborn
Kidney Transplantation
Lymphocytes
Mothers
Neonates
Pediatrics
Pneumococcal Vaccines - therapeutic use
Pregnancy
Pregnancy Complications - epidemiology
Prenatal Exposure Delayed Effects - epidemiology
Prospective Studies
Solid organ transplantation
Streptococcus infections
Streptococcus pneumoniae
Subpopulations
Tetanus
Transplant Recipients
Transplants & implants
Vaccination
Vaccine
Vaccines
Young Adult
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Summary:Highlights • Infants born to solid organ transplanted women are exposed to immunosuppression. • Eighty percent of infants born to renal transplant mothers had low B cells at birth. • Adequate humoral response to tetanus, Hib and pneumococcal vaccination was observed. • BCG healing was adequate and similar to controls. • Local and systemic vaccine reactogenicity was similar to controls.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2015.12.017