Role of dorsal hippocampal orexin-1 receptors in memory restoration induced by morphine sensitization phenomenon

Highlights • Pre-training administration of morphine impaired memory acquisition/retrieval in MWM. • Amnesia induced by morphine inhibited in morphine-sensitized rats. • Repeated or acute intra-CA1 injection of SB-334867 did not alter morphine-induced amnesia. • Repeated CA1 OX1 Rs blockade had no e...

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Bibliographic Details
Published in:Neuroscience 2016-01, Vol.312, p.215-226
Main Authors: Alijanpour, S, Tirgar, F, Zarrindast, M.-R
Format: Article
Language:English
Subjects:
Amnesia - chemically induced
Amnesia - drug therapy
Animals
Behavior, Animal - drug effects
Behavior, Animal - physiology
Benzoxazoles - administration & dosage
Benzoxazoles - pharmacology
CA1 Region, Hippocampal - drug effects
CA1 regions
Central Nervous System Sensitization - drug effects
Central Nervous System Sensitization - physiology
Male
Maze Learning - drug effects
Maze Learning - physiology
Morphine - administration & dosage
Morphine - pharmacology
morphine sensitization
morris water maze
Narcotics - administration & dosage
Narcotics - pharmacology
Neurology
Orexin Receptors - drug effects
Orexin Receptors - physiology
OX1 receptors
rat
Rats
Rats, Wistar
Receptors, Neuropeptide - antagonists & inhibitors
Spatial Memory - drug effects
Spatial Memory - physiology
Urea - administration & dosage
Urea - analogs & derivatives
Urea - pharmacology
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Summary:Highlights • Pre-training administration of morphine impaired memory acquisition/retrieval in MWM. • Amnesia induced by morphine inhibited in morphine-sensitized rats. • Repeated or acute intra-CA1 injection of SB-334867 did not alter morphine-induced amnesia. • Repeated CA1 OX1 Rs blockade had no effect on memory in morphine-sensitized rats. • SB-334867 injection in the expression phase disrupted memory induced by morphine sensitization.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.11.023