Inhibitory Effects of Crude Salts on the Induction and Development of Colonic Aberrant Crypt Foci in F-344 Rats Given Azoxymethane

The present study was designed to investigate the modifying effects of dietary exposure to NaCl and four kinds of crude salts on the induction and development of aberrant crypt foci in Fischer 344 rats. A total of 57 male rats were divided into five groups at six weeks of age, and all were given wee...

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Bibliographic Details
Published in:Nutrition and cancer 2000-01, Vol.37 (1), p.78-81
Main Authors: Masaoka, Yoshiyuki, Katoh, Osamu, Watanabe, Hiromitsu
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Azoxymethane - administration & dosage
Biological and medical sciences
Carcinogenesis, carcinogens and anticarcinogens
Carcinogens - administration & dosage
Colon - drug effects
Colon - pathology
Colonic Neoplasms - chemically induced
Colonic Neoplasms - prevention & control
Foods and miscellaneous
Gastroenterology. Liver. Pancreas. Abdomen
Male
Medical sciences
Precancerous Conditions - chemically induced
Precancerous Conditions - prevention & control
Rats
Rats, Inbred F344
Salts - chemistry
Salts - pharmacology
Salts - therapeutic use
sodium chloride
Sodium Chloride, Dietary - administration & dosage
Sodium Chloride, Dietary - pharmacology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Summary:The present study was designed to investigate the modifying effects of dietary exposure to NaCl and four kinds of crude salts on the induction and development of aberrant crypt foci in Fischer 344 rats. A total of 57 male rats were divided into five groups at six weeks of age, and all were given weekly injections of azoxymethane (15 mg/kg body wt sc) for three weeks. Group 1 was fed a normal diet throughout the experiment as control group. Groups 2, 3, 4, and 5 were fed diets containing 4.4% pure NaCl, 4.4% cooking salt, 4.4% rock salt, and 4.4% beach salt, respectively, from one week before the first azoxymethane dosing. The mean numbers of aberrant crypt foci and aberrant crypts per colon were significantly lower in Groups 3-5 than in Group 1 (p < 0.01). The present results suggest that the other mineral components (e.g., calcium and magnesium) of these crude salts, rather than pure NaCl, may be chemopreventive agents for colonic tumorigenesis.
ISSN:0163-5581
1532-7914
DOI:10.1207/S15327914NC3701_10