Circulating CD4 and CD8 T cells expressing pro-inflammatory cytokines in a cohort of mesial temporal lobe epilepsy patients with hippocampal sclerosis

Highlights • mTLE patients showed reduced frequency of CD8+ T lymphocytes expressing IFN-γ, TNF-α. • mTLE patients showed reduced frequency of CD8+ T lymphocytes expressing IL-17, IL-4. • mTLE patients presented increased frequency of CD4+ T lymphocytes expressing IL-6. • No difference was observed...

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Bibliographic Details
Published in:Epilepsy research 2016-02, Vol.120, p.1-6
Main Authors: Rosa, Daniela Valadão, Rezende, Vitor Bortolo, Costa, Bruno Silva, Mudado, Fernando, Schütze, Manuel, Torres, Karen Cecília, Martins, Luíza Conceição, Moreira-Filho, Carlos Alberto, Miranda, Debora Marques, Romano-Silva, Marco Aurélio
Format: Article
Language:English
Subjects:
Adult
CD3 Complex - metabolism
CD4-Positive T-Lymphocytes - metabolism
CD8-Positive T-Lymphocytes - metabolism
Cohort Studies
Drug Resistant Epilepsy - immunology
Drug Resistant Epilepsy - pathology
Drug-resistant
Epilepsy, Temporal Lobe - immunology
Epilepsy, Temporal Lobe - pathology
Female
Flow Cytometry
Hippocampus - pathology
Humans
Immune markers
Interferon-gamma - metabolism
Interleukin-17 - metabolism
Interleukin-4 - metabolism
Interleukin-6 - metabolism
Male
Mesial temporal lobe epilepsy
Middle Aged
Neurology
Sclerosis - pathology
Surgery
Tumor Necrosis Factor-alpha - metabolism
Young Adult
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Summary:Highlights • mTLE patients showed reduced frequency of CD8+ T lymphocytes expressing IFN-γ, TNF-α. • mTLE patients showed reduced frequency of CD8+ T lymphocytes expressing IL-17, IL-4. • mTLE patients presented increased frequency of CD4+ T lymphocytes expressing IL-6. • No difference was observed on the frequency of CD3+ CD4+ and CD3+ CD8+ T cells.
ISSN:0920-1211
1872-6844
DOI:10.1016/j.eplepsyres.2015.11.011