Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH)—An uncommon precursor of a common cancer?

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare, likely under recognized entity. We report on six cases of DIPNECH that were seen in Saskatoon, SK. The cases largely have the characteristics of the typical patient profile thus far described in the literature, consist...

Full description

Saved in:
Bibliographic Details
Published in:Pathology, research and practice research and practice, 2016-02, Vol.212 (2), p.125-129
Main Authors: Baniak, Nick M., Wilde, Brent, Kanthan, Rani
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma - pathology
Adenocarcinoma of Lung
Aged
Aged, 80 and over
Cell Transformation, Neoplastic - pathology
Diagnostic criteria
DIPNECH
Disease Progression
Female
Humans
Hyperplasia
Lung Neoplasms - pathology
Male
Middle Aged
Neoplasms, Squamous Cell - pathology
Neuroendocrine Cells - pathology
Precancerous Conditions - pathology
Saskatchewan
Squamous cell carcinoma
Tumorigenesis
Tumorlet/carcinoid
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare, likely under recognized entity. We report on six cases of DIPNECH that were seen in Saskatoon, SK. The cases largely have the characteristics of the typical patient profile thus far described in the literature, consistent with the limited information reported to date. Furthermore, one case had co-existing squamous cell carcinoma, which has not been previously described, and one case had concomitant adenocarcinoma. In this context, we explore the hypothesis of whether DIPNECH could play a role as an uncommon precursor in pulmonary tumorigenesis. We also propose improved diagnostic criteria for DIPNECH, which are currently ill-defined.
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2015.12.006