Effects of pomegranate extract supplementation on inflammation in overweight and obese individuals: A randomized controlled clinical trial

Abstract The study was designed to determine the effect of thirty days of pomegranate extract oral supplementation on plasma inflammatory and oxidative stress biomarkers as well as serum metabolic profiles, in overweight and obese individuals. In this randomized, double-blind, placebo-controlled stu...

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Bibliographic Details
Published in:Complementary therapies in clinical practice 2016-02, Vol.22, p.44-50
Main Authors: Hosseini, Banafshe, Saedisomeolia, Ahmad, Wood, Lisa G, Yaseri, Mehdi, Tavasoli, Sanaz
Format: Article
Language:English
Subjects:
Administration, Oral
Adult
Antioxidants - analysis
Diet
Dietary Supplements
Humans
Inflammation
Inflammation - complications
Inflammation - drug therapy
Internal Medicine
Lipid peroxidation
Medical Education
Middle Aged
Nursing
Obesity
Obesity - complications
Overweight - complications
Phytotherapy
Plant Extracts - administration & dosage
Plant Extracts - therapeutic use
Polyphenols
Pomegranate extract
Punicaceae
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Summary:Abstract The study was designed to determine the effect of thirty days of pomegranate extract oral supplementation on plasma inflammatory and oxidative stress biomarkers as well as serum metabolic profiles, in overweight and obese individuals. In this randomized, double-blind, placebo-controlled study 48 obese and overweight participants were randomly assigned to receive either 1000 mg of pomegranate extract, or a placebo, daily for 30 days. At baseline, and after 30 days of treatment, anthropometric parameters, dietary intake, plasma concentrations of malondialdehyde, interleukin-6 and hyper sensitive-C reactive protein and levels of serum lipids, glucose and insulin were assessed. Thirty days of PE supplementation resulted in a significant decrease in mean serum levels of glucose, insulin, total cholesterol, LDL-C, and plasma MDA, IL-6 and hs-CRP. HDL-C significantly increased following the PE versus the PL intervention. Our study suggests that pomegranate extract consumption may reduce complications linked with obesity.
ISSN:1744-3881
1873-6947
DOI:10.1016/j.ctcp.2015.12.003