Diffusion-Weighted Magnetic Resonance Imaging in Patients with Prostate Cancer Treated with Radiotherapy

Aims To evaluate the utility of a multiparametric 3T magnetic resonance imaging (MRI) study using diffusion-weighted images (DWI) for the assessment of prostate cancer before and after radiotherapy (RT). Methods A total of 34 patients, who received a histologic diagnosis of prostate adenocarcinoma,...

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Bibliographic Details
Published in:Tumori 2016-01, Vol.102 (1), p.71-76
Main Authors: Iannelli, Giancarlo, Caivano, Rocchina, Rago, Luciana, Simeon, Vittorio, Lotumolo, Antonella, Rabasco, Paola, Villonio, Antonio, Gioioso, Matilde, Mastrangelo, Pietro, Barchetti, Flavio, Panebianco, Valeria, Macarini, Luca, Guglielmi, Giuseppe, Cammarota, Aldo
Format: Article
Language:English
Subjects:
Adenocarcinoma - blood
Adenocarcinoma - pathology
Adenocarcinoma - radiotherapy
Aged
Aged, 80 and over
Biomarkers, Tumor - blood
Diffusion Magnetic Resonance Imaging - methods
Feasibility Studies
Humans
Male
Neoplasm Grading
Prospective Studies
Prostate-Specific Antigen - blood
Prostatic Neoplasms - blood
Prostatic Neoplasms - pathology
Prostatic Neoplasms - radiotherapy
Reproducibility of Results
Sample Size
Treatment Outcome
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Summary:Aims To evaluate the utility of a multiparametric 3T magnetic resonance imaging (MRI) study using diffusion-weighted images (DWI) for the assessment of prostate cancer before and after radiotherapy (RT). Methods A total of 34 patients, who received a histologic diagnosis of prostate adenocarcinoma, underwent MRI examination before and after local RT for the assessment of response to treatment. Apparent diffusion coefficient (ADC) values were calculated and compared. Results Before RT, DWI shows pathologic restriction of signal, while after RT pathologic restriction of signal was reduced or disappeared. The ADC values were significantly increased after therapy (p
ISSN:0300-8916
2038-2529
DOI:10.5301/tj.5000415