1,1′-Carbonyldiimidazole (CDI) Mediated Coupling and Cyclization To Generate [1,2,4]Triazolo­[4,3‑a]pyridines

An operationally efficient CDI mediated tandem coupling and cyclization reaction to generate [1,2,4]­triazolo­[4,3-a]­pyridines has been reported. The reaction conditions and scope were investigated, and the methodology was demonstrated in batch mode as well as in a continuous process.

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Bibliographic Details
Published in:Organic letters 2016-02, Vol.18 (3), p.560-563
Main Authors: Baucom, Kyle D, Jones, Siân C, Roberts, Scott W
Format: Article
Language:English
Subjects:
Catalysis
Cyclization
Imidazoles - chemistry
Molecular Structure
Pyridines - chemical synthesis
Pyridines - chemistry
Triazoles - chemical synthesis
Triazoles - chemistry
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Description
Summary:An operationally efficient CDI mediated tandem coupling and cyclization reaction to generate [1,2,4]­triazolo­[4,3-a]­pyridines has been reported. The reaction conditions and scope were investigated, and the methodology was demonstrated in batch mode as well as in a continuous process.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.5b03589