Atrial arrhythmogenesis in obstructive sleep apnea: Therapeutic implications

Summary The prevalence of sleep disordered breathing like obstructive sleep apnea (OSA) among patients with atrial fibrillation (AF) is 40–50%. OSA reduces success rate of catheter based and pharmacological antiarrhythmic treatment. Additionally, efficient treatment of OSA by continuous positive air...

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Bibliographic Details
Published in:Sleep medicine reviews 2016-04, Vol.26, p.87-94
Main Authors: Linz, Dominik, Linz, Benedikt, Hohl, Mathias, Böhm, Michael
Format: Article
Language:English
Subjects:
Animal experiment
Atrial electrophysiology
Atrial fibrillation
Atrial Fibrillation - etiology
Atrial Fibrillation - physiopathology
Catheter Ablation
Continuous positive airway pressure
Continuous Positive Airway Pressure - instrumentation
Continuous Positive Airway Pressure - methods
Humans
Models, Animal
Neurology
Obstructive sleep apnea
Renal denervation
Risk Factors
Sleep Apnea, Obstructive - complications
Sleep Apnea, Obstructive - physiopathology
Sleep Apnea, Obstructive - therapy
Sleep Medicine
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Summary:Summary The prevalence of sleep disordered breathing like obstructive sleep apnea (OSA) among patients with atrial fibrillation (AF) is 40–50%. OSA reduces success rate of catheter based and pharmacological antiarrhythmic treatment. Additionally, efficient treatment of OSA by continuous positive airway pressure ventilation (CPAP), the first line therapy of OSA, has been shown to improve catheter ablation success rates in AF-patients. A systematic literature search using several databases was performed to review the pathophysiology of obstructive apneas in OSA potentially leading to the development of a substrate for AF and to explain potential mechanisms involved in the clinically observed atrial antiarrhythmic effect of effective CPAP therapy.
ISSN:1087-0792
1532-2955
DOI:10.1016/j.smrv.2015.03.003