Compacting Chromatin to Ensure Muscle Satellite Cell Quiescence

Satellite cells comprise a pool of quiescent stem cells that repair muscle damage, but the mechanisms enforcing their quiescence are poorly defined. In this issue of Cell Stem Cell, Boonsanay et al. (2016) show that the histone methyltransferase Suv4-20H1 maintains satellite cell quiescence by promo...

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Bibliographic Details
Published in:Cell stem cell 2016-02, Vol.18 (2), p.162-164
Main Authors: Li, Yuefeng, Dilworth, F. Jeffrey
Format: Article
Language:English
Subjects:
Cell Differentiation
Chromatin
Humans
Muscle, Skeletal
Satellite Cells, Skeletal Muscle
Stem Cells
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Summary:Satellite cells comprise a pool of quiescent stem cells that repair muscle damage, but the mechanisms enforcing their quiescence are poorly defined. In this issue of Cell Stem Cell, Boonsanay et al. (2016) show that the histone methyltransferase Suv4-20H1 maintains satellite cell quiescence by promoting a heterochromatic state through transcriptional repression of the myogenic master regulator MyoD. Satellite cells comprise a pool of quiescent stem cells that repair muscle damage, but the mechanisms enforcing their quiescence are poorly defined. In this issue of Cell Stem Cell, Boonsanay et al. (2016) show that the histone methyltransferase Suv4-20H1 maintains satellite cell quiescence by promoting a heterochromatic state through transcriptional repression of the myogenic master regulator MyoD.
ISSN:1934-5909
1875-9777
DOI:10.1016/j.stem.2016.01.009