Copper-Catalyzed Regioselective C–H Sulfonylation of 8‑Aminoquinolines

Copper­(I)-catalyzed 5-sulfonation of quinolines via bidentate-chelation assistance has been developed. The reaction is compatible with a wide range of quinoline substrates and arylsulfonyl chlorides. Experimental and theoretical (DFT) investigation implicated that a single-electron-transfer process...

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Bibliographic Details
Published in:Journal of organic chemistry 2016-02, Vol.81 (3), p.946-955
Main Authors: Wei, Jun, Jiang, Jingxing, Xiao, Xinsheng, Lin, Dongen, Deng, Yuanfu, Ke, Zhuofeng, Jiang, Huanfeng, Zeng, Wei
Format: Article
Language:English
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Summary:Copper­(I)-catalyzed 5-sulfonation of quinolines via bidentate-chelation assistance has been developed. The reaction is compatible with a wide range of quinoline substrates and arylsulfonyl chlorides. Experimental and theoretical (DFT) investigation implicated that a single-electron-transfer process is involved in this sulfonylation transformation.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.5b02509