Antidiabetic Effects of Simple Phenolic Acids: A Comprehensive Review

Diabetes mellitus (DM) has become a major public health threat across the globe. Current antidiabetic therapies are based on synthetic drugs that very often have side effects. It has been widely acknowledged that diet plays an important role in the management of diabetes. Phenolic acids are widely f...

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Bibliographic Details
Published in:Phytotherapy research 2016-02, Vol.30 (2), p.184-199
Main Authors: Vinayagam, Ramachandran, Jayachandran, Muthukumaran, Xu, Baojun
Format: Article
Language:English
Subjects:
antidiabetic
Antioxidants - chemistry
diabetes mellitus
Diabetes Mellitus - drug therapy
Diet
drugs
Edible Grain - chemistry
Fabaceae - chemistry
Fruit - chemistry
fruits
glucose
glycemic effect
glycogen
grains
Humans
Hydroxybenzoates - pharmacology
Hypoglycemic Agents - pharmacology
insulin
legumes
lipids
medicinal plants
Oxidative Stress
phenolic acid
phenolic acids
Plants, Medicinal - chemistry
vegetables
wines
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Summary:Diabetes mellitus (DM) has become a major public health threat across the globe. Current antidiabetic therapies are based on synthetic drugs that very often have side effects. It has been widely acknowledged that diet plays an important role in the management of diabetes. Phenolic acids are widely found in daily foods such as fruits, vegetables, cereals, legumes, and wine and they provide biological, medicinal, and health properties. Simple phenolic acids have been shown to increase glucose uptake and glycogen synthesis, improve glucose and lipid profiles of certain diseases (obesity, cardiovascular diseases, DM, and its complication). The current review is an attempt to list out the antidiabetic effects of simple phenolic acids from medicinal plants and botanical foods. Copyright © 2015 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.5528