Dexmedetomidine Attenuates Myocardial Injury in Off-Pump Coronary Artery Bypass Graft Surgery

Objective To investigate the cardioprotective effect of the continuous administration of dexmedetomidine using serum cardiac troponin I (cTnI) and creatine kinase MB (CK-MB) concentrations as biomarkers during off-pump coronary artery bypass grafting (OPCAB) surgery. Design A prospective, randomized...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cardiothoracic and vascular anesthesia 2016-01, Vol.30 (1), p.44-50
Main Authors: Chi, Xiaohui, MD, Liao, Mingfeng, MD, Chen, Xin, MD, Zhao, Yilin, MD, PhD, Yang, Liu, MD, Luo, Ailin, MD, PhD, Yang, Hui, MD, PhD
Format: Article
Language:English
Subjects:
Anesthesia & Perioperative Care
Biomarkers - blood
cardioprotective
Coronary Artery Bypass, Off-Pump - adverse effects
creatine kinase MB
Critical Care
dexmedetomidine
Dexmedetomidine - administration & dosage
Drug Therapy, Combination
Female
Heart Injuries - diagnosis
Heart Injuries - drug therapy
Humans
Male
Methyl Ethers - administration & dosage
Middle Aged
off-pump coronary artery bypass grafting
Postoperative Complications - diagnosis
Postoperative Complications - drug therapy
Prospective Studies
troponin
Troponin I - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective To investigate the cardioprotective effect of the continuous administration of dexmedetomidine using serum cardiac troponin I (cTnI) and creatine kinase MB (CK-MB) concentrations as biomarkers during off-pump coronary artery bypass grafting (OPCAB) surgery. Design A prospective, randomized, parallel-group controlled study. Setting A university hospital. Participants One hundred sixteen patients undergoing OPCAB surgery. Interventions Patients were divided randomly into 3 experimental groups that were separated by the dexmedetomidine administration protocol: a high-dose group (loading dose, 1 μg/kg; maintenance dose, 0.6 μg/kg/h); low-dose group (loading dose, 0.6 μg/kg; maintenance dose, 0.3 μg/kg/h); and control group (the same amount of 0.9% saline as placebo). Serum cTnI and CK-MB levels were measured before surgery and 24 hours and 48 hours after surgery. Measurements and Main Results Serum cTnI and CK-MB levels in patients of the high-dose group were less than those of the other 2 groups 48 hours after surgery. The administration of dexmedetomidine significantly decreased the heart rate. Compared with the control group, there was a significantly reduced requirement of sevoflurane in the other 2 groups (p
ISSN:1053-0770
1532-8422
DOI:10.1053/j.jvca.2015.06.026