Gonadectomy and persistent pain differently affect hippocampal c-Fos expression in male and female rats

Hippocampal c-Fos expression was studied in male and female rats after gonadectomy and persistent pain. Three weeks after surgery, animals were sham- or formalin-injected (50 μl, 10%) and placed in a familiar testing apparatus. The formalin-evoked licking, flexing and jerking of the injected paw wer...

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Bibliographic Details
Published in:Neuroscience letters 2000-03, Vol.281 (1), p.29-32
Main Authors: Aloisi, Anna Maria, Ceccarelli, Ilaria, Herdegen, Thomas
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Biological and medical sciences
Castration - adverse effects
Dentate Gyrus - metabolism
Female
Formaldehyde - adverse effects
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Gonadal hormones
Hippocampus
Hippocampus - metabolism
Male
Pain
Pain - etiology
Pain - physiopathology
Pain Measurement
Proto-Oncogene Proteins c-fos - genetics
Rats
Rats, Wistar
Sex differences
Sex Factors
Somesthesis and somesthetic pathways (proprioception, exteroception, nociception)
interoception
electrolocation. Sensory receptors
Vertebrates: nervous system and sense organs
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Summary:Hippocampal c-Fos expression was studied in male and female rats after gonadectomy and persistent pain. Three weeks after surgery, animals were sham- or formalin-injected (50 μl, 10%) and placed in a familiar testing apparatus. The formalin-evoked licking, flexing and jerking of the injected paw were recorded for 60 min, c-Fos was determined in the dorsal and ventral hippocampus: dentate gyrus (DG), CA1 and CA3. Gonadectomy induced higher c-Fos in the dorsal DG of both sexes, in all ventral subfields of males and in the ventral CA3 of females. In normal males and females, formalin increased c-Fos in the dorsal DG and in the male ventral subfields. In gonadectomized ones formalin decreased or did not change c-Fos. Gonadectomy induced longer flexing in males and females. These data indicate an important and sex-dependent interaction between gonadal hormones, nociceptive input and neuronal activity in the hippocampus.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(00)00819-3