Increased vitamin D levels at birth and in early infancy increase offspring allergy risk—evidence for involvement of epigenetic mechanisms

Both allergy-preventing and allergy-promoting effects have been reported. [...]a deeper mechanistic understanding of how vitamin D is related to the regulation of immune reactivity and allergic inflammation is required. [...]only 26% of the genes identified as regulated by vitamin D have a vitamin D...

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Published in:Journal of allergy and clinical immunology 2016-02, Vol.137 (2), p.610-613
Main Authors: Junge, Kristin M., PhD, Bauer, Tobias, PhD, Geissler, Stefanie, PhD, Hirche, Frank, PhD, Thürmann, Loreen, MSc, Bauer, Mario, MD, Trump, Saskia, PhD, Bieg, Matthias, MSc, Weichenhan, Dieter, PhD, Gu, Lei, PhD, Mallm, Jan-Philipp, PhD, Ishaque, Naveed, PhD, Mücke, Oliver, Röder, Stefan, PhD, Herberth, Gunda, PhD, Diez, Ulrike, MD, Borte, Michael, MD, Rippe, Karsten, PhD, Plass, Christoph, PhD, Hermann, Carl, PhD, Stangl, Gabriele I., PhD, Eils, Roland, PhD, Lehmann, Irina, PhD
Format: Article
Language:English
Subjects:
Allergy and Immunology
Disease Susceptibility
DNA Methylation
Eczema
Epigenesis, Genetic
Food allergies
Genome-Wide Association Study
Humans
Hypersensitivity - epidemiology
Hypersensitivity - etiology
Infant
Infant, Newborn
Odds Ratio
Risk
Vitamin D
Vitamin D - blood
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Summary:Both allergy-preventing and allergy-promoting effects have been reported. [...]a deeper mechanistic understanding of how vitamin D is related to the regulation of immune reactivity and allergic inflammation is required. [...]only 26% of the genes identified as regulated by vitamin D have a vitamin D response element in proximity to their transcription start site (TSS),1 indicating that additional mechanisms are involved in the transcriptional control by vitamin D. As an additional mechanism, epigenetically mediated transcriptional deregulation through vitamin D-induced changes in DNA methylation was suggested.2 Here, we studied DNA-methylation pattern on a genomewide scale at base-pair resolution in healthy newborn children with high and low vitamin D levels to elucidate the role of vitamin D in epigenetic programming of an allergy-protective or allergy-promoting immune reactivity.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2015.06.040