Efficacy of T-cell transcription factor–specific DNAzymes in murine skin inflammation models

[...]efficacy of the GATA-3-specific DNAzyme approach has been shown in mouse models of allergic airway inflammation4 and most recently in a phase IIa clinical trial in which inhalation of this compound resulted in significant abrogation of allergen-induced early- and late-phase allergic responses i...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2016-02, Vol.137 (2), p.644-647.e8
Main Authors: Purath, Ulrich, PhD, Ibrahim, Rouba, BSc, Zeitvogel, Jana, PhD, Renz, Harald, MD, Runkel, Frank, PhD, Schmidts, Thomas, PhD, Dobler, Dorota, PhD, Werfel, Thomas, MD, Müller, Anke, PhD, Garn, Holger, PhD
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antigens
Cytokines
Dermatitis - genetics
Dermatitis - immunology
Dermatitis - metabolism
Dermatitis - pathology
Disease
Disease Models, Animal
DNA, Catalytic - genetics
DNA, Catalytic - metabolism
Flow cytometry
Immunoglobulins
Inflammation
Lymphocytes
Mice
Neutrophils
Protein expression
Proteins
Rodents
Skin diseases
Statistical analysis
T-Lymphocyte Subsets - immunology
T-Lymphocyte Subsets - metabolism
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
Transcription factors
Transcription Factors - genetics
Transcription Factors - metabolism
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Summary:[...]efficacy of the GATA-3-specific DNAzyme approach has been shown in mouse models of allergic airway inflammation4 and most recently in a phase IIa clinical trial in which inhalation of this compound resulted in significant abrogation of allergen-induced early- and late-phase allergic responses in patients with asthma.5 To investigate DNAzyme efficacy in inflammatory skin conditions, different mouse models were established. Because the oxazolone model induced a mixed TH1/TH2 inflammatory phenotype based on TH2- and TH1-cell activities, potential effects of topical treatment with the mouse Tbet-specific DNAzyme mtd32 were also investigated in this model.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2015.09.022