Cancer stem cells in drug resistant lung cancer: Targeting cell surface markers and signaling pathways

Lung cancer is the leading cause of cancer mortality worldwide. Despite advances in anti-cancer therapies such as chemotherapy, radiotherapy and targeted therapies, five-year survival rates remain poor (

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Bibliographic Details
Published in:Pharmacology & therapeutics (Oxford) 2016-02, Vol.158, p.71-90
Main Authors: Leon, Gemma, MacDonagh, Lauren, Finn, Stephen P, Cuffe, Sinead, Barr, Martin P
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Biomarkers, Tumor - metabolism
Drug Resistance, Neoplasm - drug effects
Humans
Lung Neoplasms - drug therapy
Neoplastic Stem Cells - drug effects
Neoplastic Stem Cells - metabolism
Signal Transduction - drug effects
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Description
Summary:Lung cancer is the leading cause of cancer mortality worldwide. Despite advances in anti-cancer therapies such as chemotherapy, radiotherapy and targeted therapies, five-year survival rates remain poor (
ISSN:0163-7258
1879-016X
DOI:10.1016/j.pharmthera.2015.12.001