Generalized periodic discharges and ‘triphasic waves’: A blinded evaluation of inter-rater agreement and clinical significance

Highlights • Generalized periodic discharges characterized as ‘triphasic waves’ present similar risk for the development of seizures as those without triphasic appearance. • ‘Triphasic waves’ have only fair inter-rater agreement ( k = 0.33) and are not reliably associated with underlying toxic-metab...

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Bibliographic Details
Published in:Clinical neurophysiology 2016-02, Vol.127 (2), p.1073-1080
Main Authors: Foreman, Brandon, Mahulikar, Advait, Tadi, Prasanna, Claassen, Jan, Szaflarski, Jerzy, Halford, Jonathan J, Dean, Brian C, Kaplan, Peter W, Hirsch, Lawrence J, LaRoche, Suzette
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Brain Waves - physiology
Cohort Studies
Critical care
EEG monitoring
Electroencephalography - methods
Electroencephalography - standards
Humans
Inter-rater agreement
Middle Aged
Neurology
Observer Variation
Periodic discharges
Prospective Studies
Seizures
Seizures - diagnosis
Seizures - physiopathology
Single-Blind Method
Triphasic waves
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Summary:Highlights • Generalized periodic discharges characterized as ‘triphasic waves’ present similar risk for the development of seizures as those without triphasic appearance. • ‘Triphasic waves’ have only fair inter-rater agreement ( k = 0.33) and are not reliably associated with underlying toxic-metabolic encephalopathy. • Conventional association of ‘triphasic waves’ with specific clinical conditions may lead to inaccurate EEG interpretation.
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2015.07.018