Rhodium complexes as therapeutic agents

The landscape of inorganic medicinal chemistry has been dominated by the investigation of platinum, and to a lesser extent ruthenium, complexes over the past few decades. Recently, complexes based on other metal centers such as rhodium have attracted attention due to their tunable chemical and biolo...

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Bibliographic Details
Published in:Dalton transactions : an international journal of inorganic chemistry 2016-02, Vol.45 (7), p.2762-2771
Main Authors: Ma, Dik-Lung, Wang, Modi, Mao, Zhifeng, Yang, Chao, Ng, Chan-Tat, Leung, Chung-Hang
Format: Article
Language:English
Subjects:
Animals
Biological
Chemical compounds
Coordination Complexes - chemistry
Coordination Complexes - pharmacology
Coordination Complexes - therapeutic use
Drug Discovery - methods
Enzymes
Humans
Landscapes
Molecular Structure
Pharmacology
Platinum
Rhodium
Rhodium - chemistry
Rhodium - pharmacology
Rhodium - therapeutic use
Ruthenium
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Summary:The landscape of inorganic medicinal chemistry has been dominated by the investigation of platinum, and to a lesser extent ruthenium, complexes over the past few decades. Recently, complexes based on other metal centers such as rhodium have attracted attention due to their tunable chemical and biological properties as well as distinct mechanisms of action. This perspective highlights recent examples of rhodium complexes that show diverse biological activities against various targets, including enzymes and protein-protein interactions. This perspective highlights recent examples of rhodium complexes that show diverse biological activities against various targets, including enzymes and protein-protein interactions.
ISSN:1477-9226
1477-9234
DOI:10.1039/c5dt04338g