Radioprotective activity of Polyalthia longifolia standardized extract against X-ray radiation injury in mice

Highlights • Polyalthia longifolia significantly improved the hematological parameters in vivo. • P. longifolia significantly increased spleen colony-forming units in vivo. • P. longifolia obviously protected the liver against the damages induced by X-ray radiation. • P. longifolia protected the X-r...

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Bibliographic Details
Published in:Physica medica 2016-01, Vol.32 (1), p.150-161
Main Authors: Jothy, Subramanion L, Saito, Tamio, Kanwar, Jagat R, Chen, Yeng, Aziz, Azlan, Yin-Hui, Leong, Sasidharan, Sreenivasan
Format: Article
Language:English
Subjects:
Animals
Antioxidants - chemistry
Blood Platelets - radiation effects
Catalase - metabolism
Chromatography, Liquid
Endogenous antioxidant
Erythrocytes - radiation effects
Hematological parameters
Leukocytes - radiation effects
Lipid Peroxidation
Liver - radiation effects
Male
Mice
P. longifolia
Plant Extracts - chemistry
Plant Leaves - chemistry
Polyalthia - chemistry
Radiation Injuries - therapy
Radiation-Protective Agents - chemistry
Radiology
Radioprotectors
Rutin - chemistry
Spleen - radiation effects
Spleen colony
Stem Cells
Superoxide Dismutase - metabolism
Tandem Mass Spectrometry
Temperature
Whole-Body Irradiation
X-Rays
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Summary:Highlights • Polyalthia longifolia significantly improved the hematological parameters in vivo. • P. longifolia significantly increased spleen colony-forming units in vivo. • P. longifolia obviously protected the liver against the damages induced by X-ray radiation. • P. longifolia protected the X-ray irradiation-induced damage in mice.
ISSN:1120-1797
1724-191X
DOI:10.1016/j.ejmp.2015.10.090