Bone loss and wrist fractures after withdrawal of hormone therapy: The 15-year follow-up of the OSTPRE cohort

Highlights • Long-term HT-use protects from bone loss and wrist fracture, reducing, thus, the incidence of osteopenia and osteoporosis. • HT-use of less than 5 years does not have long-term bone protection. • The three main reasons for discontinuation of HT were resolution of menopausal symptoms, di...

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Bibliographic Details
Published in:Maturitas 2016-03, Vol.85, p.49-55
Main Authors: Saarelainen, Jarmo, Hassi, Saara, Honkanen, Risto, Koivumaa-Honkanen, Heli, Sirola, Joonas, Kröger, Heikki, Komulainen, Marja H, Tuppurainen, Marjo
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Bone Density
Bone mineral density
Cohort study
Estrogen Replacement Therapy
Female
Femur
Finland - epidemiology
Follow-Up Studies
Hormone therapy
Humans
Incidence
Internal Medicine
Longitudinal
Lumbar Vertebrae
Middle Aged
Obstetrics and Gynecology
Osteoporosis, Postmenopausal - epidemiology
Osteoporotic Fractures - epidemiology
Postmenopausal
Prospective Studies
Time Factors
Withholding Treatment
Wrist fracture
Wrist Injuries - epidemiology
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Summary:Highlights • Long-term HT-use protects from bone loss and wrist fracture, reducing, thus, the incidence of osteopenia and osteoporosis. • HT-use of less than 5 years does not have long-term bone protection. • The three main reasons for discontinuation of HT were resolution of menopausal symptoms, disease and fear of adverse effects or cancer.
ISSN:0378-5122
1873-4111
DOI:10.1016/j.maturitas.2015.12.011