Residual low ADC and high FA at the resection margin correlate with poor chemoradiation response and overall survival in high-grade glioma patients

Highlights • Resection margin ADC (rmADC) correlates with survival in HGG patients. • Low rmADC correlates with shorter overall survival. • rmADC correlation with survival is stronger in non-enhancing than enhancing tumor. • Pre- chemoradiation ADC correlates better with OS than change in ADC during...

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Bibliographic Details
Published in:European journal of radiology 2016-03, Vol.85 (3), p.657-664
Main Authors: Qu, Jinrong, Qin, Lei, Cheng, Suchun, Leung, Katherine, Li, Xiang, Li, Hailiang, Dai, Jianping, Jiang, Tao, Akgoz, Ayca, Seethamraju, Ravi, Wang, Qifeng, Rahman, Rifaquat, Li, Shaowu, Ai, Lin, Jiang, Tianzi, Young, Geoffrey S
Format: Article
Language:English
Subjects:
Apparent diffusion coefficient
Area Under Curve
Astrocytoma - pathology
Astrocytoma - therapy
Chemoradiotherapy - methods
Dacarbazine - analogs & derivatives
Dacarbazine - therapeutic use
Female
Fractional anisotropy
Glioblastoma - pathology
Glioblastoma - therapy
High grade glioma
Humans
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Middle Aged
Radiology
ROC Curve
Survival Analysis
Treatment Outcome
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Summary:Highlights • Resection margin ADC (rmADC) correlates with survival in HGG patients. • Low rmADC correlates with shorter overall survival. • rmADC correlation with survival is stronger in non-enhancing than enhancing tumor. • Pre- chemoradiation ADC correlates better with OS than change in ADC during RT.
ISSN:0720-048X
1872-7727
DOI:10.1016/j.ejrad.2015.12.026