Responses of markers of bone and collagen turnover to exercise, growth hormone (GH) administration, and GH withdrawal in trained adult males

To examine the interactions between acute exercise and GH on markers of bone and collagen turnover and to assess the potential for detecting GH abuse in athletes using these markers, we studied 17 aerobically trained males (age, 26.9+/-1.5 yr). Sequential studies of exercise, GH administration, and...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2000, Vol.85 (1), p.124-133
Main Authors: WALLACE, J. D, CUNEO, R. C, SONKSEN, P. H, LUNDBERG, P. A, ROSEN, T, JØRGENSEN, J. O. L, LONGOBARDI, S, KEAY, N, SACCA, L, CHRISTIANSEN, J. S, BENGTSSON, B.-A
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aging - metabolism
Biological and medical sciences
Biomarkers
Bone and Bones - metabolism
Bone Development - physiology
Collagen - metabolism
Exercise - physiology
Exercise Test
Fundamental and applied biological sciences. Psychology
Growth Hormone - adverse effects
Growth Hormone - pharmacology
Hormones - blood
Human Growth Hormone - adverse effects
Human Growth Hormone - pharmacology
Humans
Kinetics
Male
Physical Endurance - physiology
Physical Fitness - physiology
procollagen
Substance Withdrawal Syndrome - metabolism
Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports
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Summary:To examine the interactions between acute exercise and GH on markers of bone and collagen turnover and to assess the potential for detecting GH abuse in athletes using these markers, we studied 17 aerobically trained males (age, 26.9+/-1.5 yr). Sequential studies of exercise, GH administration, and GH withdrawal were undertaken. A randomized, controlled study of rest vs. exercise showed that exercise did not change serum osteocalcin; other markers of formation increased transiently (each P
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.85.1.124