Development of CD8α-Positive Dendritic Cells from a Common Myeloid Progenitor

Dendritic cells (DCs) are critical in both initiating adaptive immune responses and maintaining tolerance to self antigens. These apparently contradictory roles have been suggested to depend on different subsets of DCs that arise from either myeloid or lymphoid hematopoietic origins, respectively. A...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2000-12, Vol.290 (5499), p.2152-2154
Main Authors: Traver, David, Akashi, Koichi, Manz, Markus, Merad, Miriam, Miyamoto, Toshihiro, Engleman, Edgar G., Weissman, Irving L.
Format: Article
Language:English
Subjects:
Biological and medical sciences
CD8 antigen
Dendritic cells
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Genes
Histograms
Immunity
Immunobiology
Monocytes, macrophages
Myeloid cells: ontogeny, maturation, markers, receptors
Phenotypes
Progenitor cells
Spleen
Stem cells
T lymphocytes
Transplantation
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Summary:Dendritic cells (DCs) are critical in both initiating adaptive immune responses and maintaining tolerance to self antigens. These apparently contradictory roles have been suggested to depend on different subsets of DCs that arise from either myeloid or lymphoid hematopoietic origins, respectively. Although DC expression of CD8α is attributed to a lymphoid origin, here we show that both CD8α+and CD8α-DCs can arise from clonogenic common myeloid progenitors in both thymus and spleen. Thus, expression of CD8α is not indicative of a lymphoid origin, and phenotypic and functional differences among DC subsets are likely to reflect maturation status rather than ontogeny.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.290.5499.2152