Versatile synthesis of cationic N-heterocyclic carbene-gold() complexes containing a second ancillary ligand. Design of heterobimetallic ruthenium-gold anticancer agents

We describe a versatile and quick route to cationic gold( i ) complexes containing N-heterocyclic carbenes and a second ancillary ligand (such as phosphanes, phosphites, arsines and amines) of interest for the synthesis of compounds with potential catalytic and medicinal applications. The general sy...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2016-02, Vol.52 (15), p.3155-3158
Main Authors: Fernández-Gallardo, Jacob, Elie, Benelita T, Sanaú, Mercedes, Contel, María
Format: Article
Language:English
Subjects:
amines
antineoplastic agents
Biotechnology
Cancer
carbenes
Cationic
Cations
cell lines
chemical reactions
Colon
colorectal neoplasms
cytotoxicity
gold
Gold - chemistry
Heterocyclic Compounds - chemical synthesis
heterocyclic nitrogen compounds
Inorganic salts
kidney neoplasms
Ligands
medicinal properties
Methane - analogs & derivatives
Methane - chemistry
ruthenium
Ruthenium - chemistry
Strategy
synergism
Synthesis
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Summary:We describe a versatile and quick route to cationic gold( i ) complexes containing N-heterocyclic carbenes and a second ancillary ligand (such as phosphanes, phosphites, arsines and amines) of interest for the synthesis of compounds with potential catalytic and medicinal applications. The general synthetic strategy has been applied in the preparation of novel cationic heterobimetallic ruthenium( ii )-gold( i ) complexes that are highly cytotoxic to renal cancer Caki-1 and colon cancer HCT 116 cell lines while showing a synergistic effect and being more selective than their monometallic counterparts. A novel synthetic strategy to incorporate a second neutral ligand in [gold( i )-NHC] + fragments for the preparation of mono and multimetallic compounds.
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/c5cc09718e