Treatment of the Pregnant Patient with Inflammatory Bowel Disease

• Published in: Inflammatory bowel diseases 2016-03, Vol.22 (3), p.733-744
• Main Authors: Winter, Rachel, Nørgård, Bente M, Friedman, Sonia
• Format: Article
• Language: English
• Subjects: Abnormalities, Drug-Induced - prevention & control; Female; Humans; Immunosuppressive Agents - therapeutic use; Inflammatory Bowel Diseases - drug therapy; Pregnancy; Pregnancy Complications - drug therapy; Pregnancy Outcome
• ISSN: 1078-0998; 1536-4844
• DOI: 10.1097/MIB.0000000000000625

Research regarding fertility, medication safety, and pregnancy outcomes is increasing, but there are still many knowledge gaps in these areas. Women with ulcerative colitis and Crohn's disease may have decreased fertility because of voluntary childlessness and inflammatory bowel disease (IBD) surgery, and women with Crohn's disease may also have decreased ovarian reserve. Initial studies show that in vitro fertilization is a viable option, and laparoscopic ileoanal pouch anastomosis surgery improves fertility rates. Additional research is needed on the effect of disease activity on fertility and on the rates of pregnancy loss and ectopic pregnancies. We do not know how to reliably measure disease activity during pregnancy or the effect of pregnancy on the microbiome. Although immunomodulators and anti-tumor necrosis factor medications are relatively safe during pregnancy, the long-term effects of these medications on the child are unknown. The recommended mode of delivery is still debated, especially for women after ileoanal pouch anastomosis. There are multiple studies on the relative safety of immunomodulators and anti-tumor necrosis factor medications during pregnancy, and we know how to safely treat a pregnant patient with a disease flare. The best way to manage women with IBD who are pregnant or contemplating pregnancy is a multidisciplinary approach. Team members often include a gastroenterologist, a high-risk obstetrician, an infertility specialist, a colorectal surgeon, and a pediatrician with experience in caring for children of mothers with IBD. By integrating expertise from these disciplines, women with even very complex IBD should be able to have a healthy pregnancy and delivery.