Role of linoleic acid in arsenical palmar keratosis

Background Chronic arsenic exposure can lead to palmoplantar keratosis. In the stratum corneum of skin, linoleic acid is of the utmost importance to the inflammation, keratinization, and regeneration processes. Objectives The aims of this study were: (i) to present quantitative information on the li...

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Bibliographic Details
Published in:International journal of dermatology 2016-03, Vol.55 (3), p.289-295
Main Authors: Ahmed, Tarafder S., Misbahuddin, Mir
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Arsenic - analysis
Arsenic Poisoning - complications
Arsenic Poisoning - urine
Bangladesh
Case-Control Studies
Drinking Water - chemistry
Female
Hand Dermatoses - chemically induced
Hand Dermatoses - metabolism
Hand Dermatoses - urine
Humans
Keratoderma, Palmoplantar - chemically induced
Keratoderma, Palmoplantar - metabolism
Keratoderma, Palmoplantar - urine
Linoleic Acid - metabolism
Male
Middle Aged
Young Adult
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Summary:Background Chronic arsenic exposure can lead to palmoplantar keratosis. In the stratum corneum of skin, linoleic acid is of the utmost importance to the inflammation, keratinization, and regeneration processes. Objectives The aims of this study were: (i) to present quantitative information on the linoleic acid fraction of intercorneocyte lipids, and (ii) to elucidate the role of linoleic acid in the pathophysiology of arsenical keratosis. Methods Lipid extracts were collected from keratotic lesions in seven patients, seven arsenic‐exposed subjects, and seven non‐exposed control subjects. Linoleic acid levels of the specimens were estimated by reverse‐phase high‐performance liquid chromatography (RP‐HPLC). Results There was a significant (P 
ISSN:0011-9059
1365-4632
DOI:10.1111/ijd.12831