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Role of linoleic acid in arsenical palmar keratosis
Background Chronic arsenic exposure can lead to palmoplantar keratosis. In the stratum corneum of skin, linoleic acid is of the utmost importance to the inflammation, keratinization, and regeneration processes. Objectives The aims of this study were: (i) to present quantitative information on the li...
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| Published in: | International journal of dermatology 2016-03, Vol.55 (3), p.289-295 |
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| Language: | English |
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| container_title | International journal of dermatology |
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| creator | Ahmed, Tarafder S. Misbahuddin, Mir |
| description | Background
Chronic arsenic exposure can lead to palmoplantar keratosis. In the stratum corneum of skin, linoleic acid is of the utmost importance to the inflammation, keratinization, and regeneration processes.
Objectives
The aims of this study were: (i) to present quantitative information on the linoleic acid fraction of intercorneocyte lipids, and (ii) to elucidate the role of linoleic acid in the pathophysiology of arsenical keratosis.
Methods
Lipid extracts were collected from keratotic lesions in seven patients, seven arsenic‐exposed subjects, and seven non‐exposed control subjects. Linoleic acid levels of the specimens were estimated by reverse‐phase high‐performance liquid chromatography (RP‐HPLC).
Results
There was a significant (P |
| doi_str_mv | 10.1111/ijd.12831 |
| format | article |
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Chronic arsenic exposure can lead to palmoplantar keratosis. In the stratum corneum of skin, linoleic acid is of the utmost importance to the inflammation, keratinization, and regeneration processes.
Objectives
The aims of this study were: (i) to present quantitative information on the linoleic acid fraction of intercorneocyte lipids, and (ii) to elucidate the role of linoleic acid in the pathophysiology of arsenical keratosis.
Methods
Lipid extracts were collected from keratotic lesions in seven patients, seven arsenic‐exposed subjects, and seven non‐exposed control subjects. Linoleic acid levels of the specimens were estimated by reverse‐phase high‐performance liquid chromatography (RP‐HPLC).
Results
There was a significant (P < 0.001) increase in mean ± standard error (SE) linoleic acid levels in arsenical keratosis patients (palm: 25.66 ± 4.95 μg/cm2; dorsum: 28.25 ± 6.20 μg/cm2) compared with arsenic‐exposed (palm: 2.75 ± 0.85 μg/cm2; dorsum: 1.96 ± 0.64 μg/cm2) and non‐exposed (palm: 1.52 ± 0.61 μg/cm2; dorsum: 1.28 ± 0.39 μg/cm2) control subjects. There was no significant difference (P = 0.556) in linoleic acid concentration in the non‐affected skin of the dorsum of the hand (28.25 ± 6.20 μg/cm2) compared with that in the palmar sites (25.66 ± 4.95 μg/cm2) in the patient group. The change in linoleic acid levels in the arsenic‐exposed control group did not differ from that in non‐exposed controls (P = 1.000).
Conclusions
Linoleic acid concentration is elevated in arsenical keratosis; this finding warrants further investigation to ascertain whether linoleic acid plays a direct role in the pathophysiology of arsenical keratosis.</description><identifier>ISSN: 0011-9059</identifier><identifier>EISSN: 1365-4632</identifier><identifier>DOI: 10.1111/ijd.12831</identifier><identifier>PMID: 26235890</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Arsenic - analysis ; Arsenic Poisoning - complications ; Arsenic Poisoning - urine ; Bangladesh ; Case-Control Studies ; Drinking Water - chemistry ; Female ; Hand Dermatoses - chemically induced ; Hand Dermatoses - metabolism ; Hand Dermatoses - urine ; Humans ; Keratoderma, Palmoplantar - chemically induced ; Keratoderma, Palmoplantar - metabolism ; Keratoderma, Palmoplantar - urine ; Linoleic Acid - metabolism ; Male ; Middle Aged ; Young Adult</subject><ispartof>International journal of dermatology, 2016-03, Vol.55 (3), p.289-295</ispartof><rights>2015</rights><rights>2015 The International Society of Dermatology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4331-dc272d6a98df36e5e6624b8424486706e8c235b0fce164267c186648d34d8b823</citedby><cites>FETCH-LOGICAL-c4331-dc272d6a98df36e5e6624b8424486706e8c235b0fce164267c186648d34d8b823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26235890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahmed, Tarafder S.</creatorcontrib><creatorcontrib>Misbahuddin, Mir</creatorcontrib><title>Role of linoleic acid in arsenical palmar keratosis</title><title>International journal of dermatology</title><addtitle>Int J Dermatol</addtitle><description>Background
Chronic arsenic exposure can lead to palmoplantar keratosis. In the stratum corneum of skin, linoleic acid is of the utmost importance to the inflammation, keratinization, and regeneration processes.
Objectives
The aims of this study were: (i) to present quantitative information on the linoleic acid fraction of intercorneocyte lipids, and (ii) to elucidate the role of linoleic acid in the pathophysiology of arsenical keratosis.
Methods
Lipid extracts were collected from keratotic lesions in seven patients, seven arsenic‐exposed subjects, and seven non‐exposed control subjects. Linoleic acid levels of the specimens were estimated by reverse‐phase high‐performance liquid chromatography (RP‐HPLC).
Results
There was a significant (P < 0.001) increase in mean ± standard error (SE) linoleic acid levels in arsenical keratosis patients (palm: 25.66 ± 4.95 μg/cm2; dorsum: 28.25 ± 6.20 μg/cm2) compared with arsenic‐exposed (palm: 2.75 ± 0.85 μg/cm2; dorsum: 1.96 ± 0.64 μg/cm2) and non‐exposed (palm: 1.52 ± 0.61 μg/cm2; dorsum: 1.28 ± 0.39 μg/cm2) control subjects. There was no significant difference (P = 0.556) in linoleic acid concentration in the non‐affected skin of the dorsum of the hand (28.25 ± 6.20 μg/cm2) compared with that in the palmar sites (25.66 ± 4.95 μg/cm2) in the patient group. The change in linoleic acid levels in the arsenic‐exposed control group did not differ from that in non‐exposed controls (P = 1.000).
Conclusions
Linoleic acid concentration is elevated in arsenical keratosis; this finding warrants further investigation to ascertain whether linoleic acid plays a direct role in the pathophysiology of arsenical keratosis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Arsenic - analysis</subject><subject>Arsenic Poisoning - complications</subject><subject>Arsenic Poisoning - urine</subject><subject>Bangladesh</subject><subject>Case-Control Studies</subject><subject>Drinking Water - chemistry</subject><subject>Female</subject><subject>Hand Dermatoses - chemically induced</subject><subject>Hand Dermatoses - metabolism</subject><subject>Hand Dermatoses - urine</subject><subject>Humans</subject><subject>Keratoderma, Palmoplantar - chemically induced</subject><subject>Keratoderma, Palmoplantar - metabolism</subject><subject>Keratoderma, Palmoplantar - urine</subject><subject>Linoleic Acid - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Young Adult</subject><issn>0011-9059</issn><issn>1365-4632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp1kE1PAjEQhhujEUQP_gGzRz0s9Gu73aMBRZRoohiNl6bbdpNCYbGFKP_e6gI35zIzyTNPJi8A5wh2UayeneouwpygA9BGhGUpZQQfgjaECKUFzIoWOAlhGleCET0GLcwwyXgB24A8184kdZU4u4iTVYlUVid2kUgfzMIq6ZKldHPpk5nxclUHG07BUSVdMGfb3gGvtzeT_l06fhqO-tfjVFFCUKoVzrFmsuC6IsxkhjFMS04xpZzlkBmu4hclrJRBjGKWK8QZo1wTqnnJMemAy8a79PXn2oSVmNugjHNyYep1EChnGULRRCN61aDK1yF4U4mlt_HpjUBQ_GYkYkbiL6PIXmy163Ju9J7chRKBXgN8WWc2_5vE6H6wU6bNhQ0r872_kH4mWE7yTLw9DkX2MBi_kI-JeCc_Z7F87A</recordid><startdate>201603</startdate><enddate>201603</enddate><creator>Ahmed, Tarafder S.</creator><creator>Misbahuddin, Mir</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201603</creationdate><title>Role of linoleic acid in arsenical palmar keratosis</title><author>Ahmed, Tarafder S. ; Misbahuddin, Mir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4331-dc272d6a98df36e5e6624b8424486706e8c235b0fce164267c186648d34d8b823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Arsenic - analysis</topic><topic>Arsenic Poisoning - complications</topic><topic>Arsenic Poisoning - urine</topic><topic>Bangladesh</topic><topic>Case-Control Studies</topic><topic>Drinking Water - chemistry</topic><topic>Female</topic><topic>Hand Dermatoses - chemically induced</topic><topic>Hand Dermatoses - metabolism</topic><topic>Hand Dermatoses - urine</topic><topic>Humans</topic><topic>Keratoderma, Palmoplantar - chemically induced</topic><topic>Keratoderma, Palmoplantar - metabolism</topic><topic>Keratoderma, Palmoplantar - urine</topic><topic>Linoleic Acid - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahmed, Tarafder S.</creatorcontrib><creatorcontrib>Misbahuddin, Mir</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahmed, Tarafder S.</au><au>Misbahuddin, Mir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of linoleic acid in arsenical palmar keratosis</atitle><jtitle>International journal of dermatology</jtitle><addtitle>Int J Dermatol</addtitle><date>2016-03</date><risdate>2016</risdate><volume>55</volume><issue>3</issue><spage>289</spage><epage>295</epage><pages>289-295</pages><issn>0011-9059</issn><eissn>1365-4632</eissn><abstract>Background
Chronic arsenic exposure can lead to palmoplantar keratosis. In the stratum corneum of skin, linoleic acid is of the utmost importance to the inflammation, keratinization, and regeneration processes.
Objectives
The aims of this study were: (i) to present quantitative information on the linoleic acid fraction of intercorneocyte lipids, and (ii) to elucidate the role of linoleic acid in the pathophysiology of arsenical keratosis.
Methods
Lipid extracts were collected from keratotic lesions in seven patients, seven arsenic‐exposed subjects, and seven non‐exposed control subjects. Linoleic acid levels of the specimens were estimated by reverse‐phase high‐performance liquid chromatography (RP‐HPLC).
Results
There was a significant (P < 0.001) increase in mean ± standard error (SE) linoleic acid levels in arsenical keratosis patients (palm: 25.66 ± 4.95 μg/cm2; dorsum: 28.25 ± 6.20 μg/cm2) compared with arsenic‐exposed (palm: 2.75 ± 0.85 μg/cm2; dorsum: 1.96 ± 0.64 μg/cm2) and non‐exposed (palm: 1.52 ± 0.61 μg/cm2; dorsum: 1.28 ± 0.39 μg/cm2) control subjects. There was no significant difference (P = 0.556) in linoleic acid concentration in the non‐affected skin of the dorsum of the hand (28.25 ± 6.20 μg/cm2) compared with that in the palmar sites (25.66 ± 4.95 μg/cm2) in the patient group. The change in linoleic acid levels in the arsenic‐exposed control group did not differ from that in non‐exposed controls (P = 1.000).
Conclusions
Linoleic acid concentration is elevated in arsenical keratosis; this finding warrants further investigation to ascertain whether linoleic acid plays a direct role in the pathophysiology of arsenical keratosis.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>26235890</pmid><doi>10.1111/ijd.12831</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Arsenic - analysis Arsenic Poisoning - complications Arsenic Poisoning - urine Bangladesh Case-Control Studies Drinking Water - chemistry Female Hand Dermatoses - chemically induced Hand Dermatoses - metabolism Hand Dermatoses - urine Humans Keratoderma, Palmoplantar - chemically induced Keratoderma, Palmoplantar - metabolism Keratoderma, Palmoplantar - urine Linoleic Acid - metabolism Male Middle Aged Young Adult |
| title | Role of linoleic acid in arsenical palmar keratosis |
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