Infectivity of Cryptosporidium hominis and Cryptosporidium parvum Genotype 2 Isolates in Immunosuppressed Mongolian Gerbils

One-month-old dexamethasone-immunosuppressed Mongolian gerbils were challenged with 1 oocyst to 2 x 10⁵ oocysts from two isolates genotyped as Cryptosporidium hominis and C. parvum (genotype 2), respectively. A similar dose-dependent gut infection was obtained, and the initial genotype maintained fo...

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Bibliographic Details
Published in:Infection and Immunity 2005-08, Vol.73 (8), p.5252-5255
Main Authors: Baishanbo, Asiya, Gargala, Gilles, Delaunay, Agnès, François, Arnaud, Ballet, Jean-Jacques, Favennec, Loi̊c
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cryptosporidiosis - immunology
Cryptosporidium parvum - genetics
Cryptosporidium parvum - immunology
Cryptosporidium parvum - pathogenicity
Fundamental and applied biological sciences. Psychology
Fungal and Parasitic Infections
Genotype
Gerbillinae
Immunosuppression
Microbiology
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Summary:One-month-old dexamethasone-immunosuppressed Mongolian gerbils were challenged with 1 oocyst to 2 x 10⁵ oocysts from two isolates genotyped as Cryptosporidium hominis and C. parvum (genotype 2), respectively. A similar dose-dependent gut infection was obtained, and the initial genotype maintained for 21 to 22 days. The data suggest that immunosuppressed gerbils provide a reliable rodent model of persistent C. hominis infection.
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.73.8.5252-5255.2005