Impact of PEG and PEG-b-PAGE modified PLGA on nanoparticle formation, protein loading and release

[Display omitted] The effect of modifying the well-established pharmaceutical polymer PLGA by different PEG-containing block-copolymers on the preparation of ovalbumin (OVA) loaded PLGA nanoparticles (NPs) was studied. The used polymers contained poly(d,l-lactic-co-glycolic acid) (PLGA), polyethylen...

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Bibliographic Details
Published in:International journal of pharmaceutics 2016-03, Vol.500 (1-2), p.187-195
Main Authors: Rietscher, René, Czaplewska, Justyna A., Majdanski, Tobias C., Gottschaldt, Michael, Schubert, Ulrich S., Schneider, Marc, Lehr, Claus-Michael
Format: Article
Language:English
Subjects:
Drug delivery
Drug Liberation
Epoxy Compounds - chemistry
Lactic Acid - chemistry
Nanoparticles - chemistry
Ovalbumin
Ovalbumin - chemistry
Particle Size
Poly(allyl glycidyl ether)
Poly(d,l-lactic-co-glycolic acid)
Polyethylene glycol
Polyethylene Glycols - chemistry
Polyglycolic Acid - chemistry
Protein delivery
Surface Properties
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Summary:[Display omitted] The effect of modifying the well-established pharmaceutical polymer PLGA by different PEG-containing block-copolymers on the preparation of ovalbumin (OVA) loaded PLGA nanoparticles (NPs) was studied. The used polymers contained poly(d,l-lactic-co-glycolic acid) (PLGA), polyethylene glycol (PEG) and poly(allyl glycidyl ether) (PAGE) as building blocks. The double emulsion technique yielded spherical NPs in the size range from 170 to 220nm (PDI
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2016.01.021