The key role of rubella virus glycoproteins in the formation of immune response, and perspectives on their use in the development of new recombinant vaccines

Highlights • Rubella is a highly contagious viral disease. • Existent live attenuated vaccines are effective but have several drawbacks. • The development of alternative non-replicating, recombinant vaccines is needed. • The role of rubella virus proteins E1 and E2 in vaccine development is discusse...

Full description

Saved in:
Bibliographic Details
Published in:Vaccine 2016-02, Vol.34 (8), p.1006-1011
Main Authors: Petrova, Ekaterina K, Dmitrieva, Anastasia A, Trifonova, Ekaterina A, Nikitin, Nikolai A, Karpova, Olga V
Format: Article
Language:English
Subjects:
Allergy and Immunology
Antigens, Viral - immunology
Arthritis
Congenital diseases
Development of recombinant vaccines
Epitopes
Epitopes - immunology
Female
Fetuses
Glycoproteins
Glycoproteins E1 and E2
Humans
Immune response
Immunoglobulins
Infections
Measles
Molecular weight
Mumps
Pregnancy
Proteins
Recombinant Proteins - immunology
Rubella - prevention & control
Rubella Vaccine - immunology
Rubella virus
Vaccines
Vaccines, Synthetic - immunology
Viral diseases
Viral Envelope Proteins - immunology
Viral infections
Womens health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • Rubella is a highly contagious viral disease. • Existent live attenuated vaccines are effective but have several drawbacks. • The development of alternative non-replicating, recombinant vaccines is needed. • The role of rubella virus proteins E1 and E2 in vaccine development is discussed.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2016.01.010