Currently known risk factors for hypertrophic skin scarring: A review

Summary Objective The study aims to provide an overview of risk factors for hypertrophic scarring. Background Hypertrophic skin scarring remains a major concern in medicine and causes considerable morbidity. Despite extensive research on this topic, the precise mechanism of excessive scarring is sti...

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Bibliographic Details
Published in:Journal of plastic, reconstructive & aesthetic surgery reconstructive & aesthetic surgery, 2016-02, Vol.69 (2), p.163-169
Main Authors: Butzelaar, L, Ulrich, M.M.W, Mink van der Molen, A.B, Niessen, F.B, Beelen, R.H.J
Format: Article
Language:English
Subjects:
Cicatrix, Hypertrophic - epidemiology
Cicatrix, Hypertrophic - etiology
Cicatrix, Hypertrophic - pathology
Excessive scarring
Global Health
Humans
Hypertrophic scar
Morbidity - trends
Plastic Surgery
Risk Factors
Skin
Skin - pathology
Wound Healing
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Summary:Summary Objective The study aims to provide an overview of risk factors for hypertrophic scarring. Background Hypertrophic skin scarring remains a major concern in medicine and causes considerable morbidity. Despite extensive research on this topic, the precise mechanism of excessive scarring is still unknown. In addition, the current literature lacks an overview of the possible risk factors in the development of hypertrophic scars. Methods PubMed searches were performed on risk factors for hypertrophic scar (HTS) formation. Results Eleven studies suggesting nine factors associated with HTS formation were found. Studies concerning chemotherapy, age, stretch, infection, and smoking have a moderate to high strength of evidence, but some other factors have not been studied in a convincing manner or are still disputed. Conclusions Risk factors for HTS formation are young age, bacterial colonization, and skin subjected to stretch. Chemotherapy, statins, and smoking seem to play a protective role in HTS formation.
ISSN:1748-6815
1878-0539
DOI:10.1016/j.bjps.2015.11.015