Liver involvement in ANCA-associated vasculitis

The aim of the study was to investigate the incidence, the clinical course and outcome of liver involvement and autoimmune hepatic diseases in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Liver function tests (LFT) (i.e. aspartate and alanine aminotransferas...

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Bibliographic Details
Published in:Clinical rheumatology 2016-02, Vol.35 (2), p.387-394
Main Authors: Willeke, Peter, Schlüter, Bernhard, Limani, Armend, Becker, Heidemarie, Schotte, Heiko
Format: Article
Language:English
Subjects:
Adult
Aged
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - complications
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - epidemiology
Female
Germany - epidemiology
Humans
Incidence
Liver Diseases - epidemiology
Liver Diseases - immunology
Liver Function Tests
Male
Medicine
Medicine & Public Health
Middle Aged
Original Article
Rheumatology
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Summary:The aim of the study was to investigate the incidence, the clinical course and outcome of liver involvement and autoimmune hepatic diseases in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Liver function tests (LFT) (i.e. aspartate and alanine aminotransferase [AST, ALT], gamma-glutamyl transpeptidase [gamma-GT], alkaline phosphatase [ALP] and total bilirubin) were analysed at disease onset in therapy-naïve patients and during remission in patients with granulomatosis with polyangiitis (GPA, n  = 67), microscopic polyangiitis (MPA, n  = 28) and eosinophilic granulomatosis with polyangiitis (EGPA, n  = 14). Results were correlated to the Birmingham Vasculitis Activity Score version 3 (BVAS v.3). Also, serologic tests for other autoimmune hepatic diseases were performed in these patients. During the active state, LFT abnormalities could be detected in 54 AAV patients (49.4 %). ALT, gamma-GT and ALP were significantly higher in GPA patients compared to MPA or EGPA patients at disease onset ( p  
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-015-2882-5