Role of Small Noncoding RNAs in Bacterial Metabolism

The study of prokaryotic small RNAs is one of the most important directions in modern molecular biology. In the last decade, multiple short regulatory transcripts have been found in prokaryotes, and for some of them functional roles have been elucidated. Bacterial small RNAs are implicated in the re...

Full description

Saved in:
Bibliographic Details
Published in:Biochemistry (Moscow) 2015-12, Vol.80 (13), p.1633-1646
Main Authors: Azhikina, T. L., Ignatov, D. V., Salina, E. G., Fursov, M. V., Kaprelyants, A. S.
Format: Article
Language:English
Subjects:
Bacteria
Bacteria - genetics
Bacteria - metabolism
Bacterial diseases
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Environmental changes
Environmental conditions
Gene expression
Gene Expression Regulation, Bacterial
Genetic aspects
Life Sciences
Metabolism
Methods
Microbiology
Molecular biology
Mycobacterium tuberculosis
Nucleic Acid Conformation
Observations
Review
Ribonucleic acid
RNA
RNA sequencing
RNA Stability
RNA, Bacterial - metabolism
RNA, Messenger - metabolism
RNA, Small Untranslated - metabolism
RNA, Small Untranslated - physiology
RNA-protein interactions
Transcription factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The study of prokaryotic small RNAs is one of the most important directions in modern molecular biology. In the last decade, multiple short regulatory transcripts have been found in prokaryotes, and for some of them functional roles have been elucidated. Bacterial small RNAs are implicated in the regulation of transcription and translation, and they affect mRNA stability and gene expression via different mechanisms, including changes in mRNA conformation and interaction with proteins. Most small RNAs are expressed in response to external factors, and they help bacteria to adapt to changing environmental conditions. Bacterial infections of various origins remain a serious medical problem, despite significant progress in fighting them. Discovery of mechanisms that bacteria employ to survive in infected organisms and ways to block these mechanisms is promising for finding new treatments for bacterial infections. Regulation of pathogenesis with small RNAs is an attractive example of such mechanisms. This review considers the role of bacterial small RNAs in adaptation to stress conditions. We pay special attention to the role of small RNAs in Mycobacterium tuberculosis infection, in particular during establishment and maintenance of latent infection.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297915130015