Evaluation of the Antiangiogenic Effects of Octreotide on Growth Hormone-producing Pituitary Adenoma using Arterial Spin-labeling Perfusion Imaging

Decreased absolute tumor blood flow (TBF) measured by arterial spin labeling perfusion imaging (ASL-PI) on 3-tesla magnetic resonance imaging demonstrated the reduced size and growth hormone (GH) secretion of a large GH-producing pituitary adenoma in a 32-year-old man in response to octreotide thera...

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Published in:Magnetic Resonance in Medical Sciences 2015/02/01, Vol.14(1), pp.73-76
Main Authors: SAKAI, Naoto, YAMASHITA, Shuhei, TAKEHARA, Yasuo, SAKAHARA, Harumi, BABA, Satoshi, OKI, Yutaka, TAKAHASHI, Goro, KOIZUMI, Shinichiro, SAMESHIMA, Tetsuro, NAMBA, Hiroki
Format: Article
Language:English
Subjects:
Adult
angiogenesis
Angiogenesis Inhibitors - pharmacology
Antineoplastic Agents, Hormonal - pharmacology
arterial spin-labeling (ASL)
Human Growth Hormone - secretion
Humans
magnetic resonance
Magnetic Resonance Imaging
Male
octreotide
Octreotide - pharmacology
pituitary adenoma
Pituitary Neoplasms - blood supply
Pituitary Neoplasms - drug therapy
Pituitary Neoplasms - secretion
Reproducibility of Results
Spin Labels
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Summary:Decreased absolute tumor blood flow (TBF) measured by arterial spin labeling perfusion imaging (ASL-PI) on 3-tesla magnetic resonance imaging demonstrated the reduced size and growth hormone (GH) secretion of a large GH-producing pituitary adenoma in a 32-year-old man in response to octreotide therapy. The study shows the usefulness of ASL-PI in providing a biomarker of the antiangiogenic effect of octreotide.
ISSN:1347-3182
1880-2206
DOI:10.2463/mrms.2014-0026