Waterborne psychoactive drugs impair the initial development of Zebrafish

Highlights • The contamination of natural water bodies by psychoactive drugs is a current reality. • Fluoxetine, diazepam and risperidone affected the initial development of zebrafish. • All drugs increase the mortality rate, heart frequency and decrease larvae length. • Risperidone and fluoxetine d...

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2016-01, Vol.41, p.89-94
Main Authors: Kalichak, Fabiana, Idalencio, Renan, Rosa, João Gabriel S, Oliveira, Thiago A. de, Koakoski, Gessi, Gusso, Darlan, Abreu, Murilo S. de, Giacomini, Ana Cristina V, Barcellos, Heloísa H.A, Fagundes, Michele, Piato, Angelo L, Barcellos, Leonardo J.G
Format: Article
Language:English
Subjects:
Animals
Danio rerio
Diazepam
Diazepam - toxicity
Embryo
Embryo, Nonmammalian - drug effects
Embryonic Development - drug effects
Emergency
Female
Fluoxetine
Fluoxetine - toxicity
Larva - drug effects
Larvae
Male
Mortality
Psychoactive drugs
Psychotropic Drugs - toxicity
Risperidone
Risperidone - toxicity
Water Pollutants, Chemical - toxicity
Zebrafish - embryology
Zebrafish - growth & development
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Summary:Highlights • The contamination of natural water bodies by psychoactive drugs is a current reality. • Fluoxetine, diazepam and risperidone affected the initial development of zebrafish. • All drugs increase the mortality rate, heart frequency and decrease larvae length. • Risperidone and fluoxetine decrease egg hatching. • These effects on early development may have significant environmental implications.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2015.11.014